Asymmetric Hydrogenation of Heteroarenes with Multiple Heteroatoms

Zhang-Pei Chen; Yong-Gui Zhou

doi:10.1055/s-0035-1561622

Synthesis, Table of Contents

Synthesis 2016; 48(12): 1769-1781
DOI: 10.1055/s-0035-1561622

short review

Asymmetric Hydrogenation of Heteroarenes with Multiple Heteroatoms

Zhang-Pei Chen

State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, P. R. of China Email: ygzhou@dicp.ac.cn

,

Yong-Gui Zhou*

State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, P. R. of China Email: ygzhou@dicp.ac.cn

› Author Affiliations

Abstract

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Abstract

Enantiopure heterocyclic architectures containing two or more heteroatoms in the ring system have attracted considerable attraction due to this motif playing a role of great importance in asymmetric synthesis and the pharmaceutical chemistry. This review focused on recent advances in the homogeneous asymmetric hydrogenation of heteroarenes with multiple heteroatoms, which provide an efficient and practical method to structural diverse chiral heterocyclic compounds.

1 Introduction

2 Asymmetric Hydrogenation of Five-Membered-Ring Heteroarenes

2.1 Imidazoles and Oxazoles

2.2 Pyrazole Derivatives

2.3 Benzisoxazoles

3 Asymmetric Hydrogenation of Six-Membered-Ring Heteroarenes

3.1 Quinoxalines

3.2 Quinazolines

3.3 Pyrimidines

3.4 Pyrazines

4 Asymmetric Hydrogenation of Fused Nitrogen Heteroarenes

4.1 Heteroarenes Containing a Ring-Junction Nitrogen

4.2 Heteroarenes Containing a Fused Pyridine Ring

5 Conclusions and Outlook

Key words

hydrogenation - enantioselectivity - heteroarenes - heterocycles - asymmetric catalysis

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References

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