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Synthesis 2016; 48(18): 3042-3049
DOI: 10.1055/s-0035-1561860
DOI: 10.1055/s-0035-1561860
paper
Synthesis of a New Polyfunctionalised Pyrimidine-4-carboxylate and Its Application for the Construction of a Series of Pyrimidine Derivatives
Further Information
Publication History
Received: 08 February 2016
Accepted after revision: 18 April 2016
Publication Date:
24 May 2016 (online)
Abstract
The synthesis of a new and versatile polyfunctionalised pyrimidine-4-carboxylate, along with the study of its reactivity against 1,2-dinucleophiles and 1,4-dinucleophiles, is reported. These simple and efficient methodologies allowed for the synthesis of novel pyrimidine derivatives such as pyrimido[4,5-d]pyridazin-8-one-5-carboxylates and their corresponding carbohydrazides and N-acylhydrazone (NAH) derivatives, pyrimido[4,5-d][1,2]oxazin-8-one and its corresponding carbohydrazide derivative, and 3-pyrimidinylquinoxaline-2-one and its corresponding carbohydrazide. Furthermore, pyrimidine hydroxyimino derivatives were also prepared.
Key words
pyrimidine-4-carboxylate - 2,4,5-trisubstituted pyrimidine - pyrimido[4,5-d]pyridazinone - pyrimido[4,5-d]oxazinone - quinoxalinoneSupporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1561860.
- Supporting Information
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