Synlett 2016; 27(11): 1711-1714
DOI: 10.1055/s-0035-1562092
letter
© Georg Thieme Verlag Stuttgart · New York

Iron-Catalyzed Oxidative Coupling Reaction of N-Acyl Glycine Esters and Malonates

Hui Yu*
a   Department of Chemistry, Tongji University, 1239 Siping Road, Shanghai, 200092, P. R. of China   Email: yuhui@tongji.edu.cn
b   Shanghai Key Laboratory of Chemical Assessment and Sustainability, 1239 Siping Road, Shanghai, 200092, P. R. of China
,
Zhongyang Liu
a   Department of Chemistry, Tongji University, 1239 Siping Road, Shanghai, 200092, P. R. of China   Email: yuhui@tongji.edu.cn
,
Jingbo Lin
a   Department of Chemistry, Tongji University, 1239 Siping Road, Shanghai, 200092, P. R. of China   Email: yuhui@tongji.edu.cn
› Author Affiliations
Further Information

Publication History

Received: 24 January 2016

Accepted after revision: 23 March 2016

Publication Date:
21 April 2016 (online)


Abstract

An iron-catalyzed direct C–C double-bond formation process is described in this paper. Using DTBP as the oxidant and FeCl3·6H2O (20 mol%) as the catalyst, N-2-pyridinecarbonyl glycine esters were coupled with malonates to provide amido acrylates in moderate to good yields. A possible reaction pathway for the formation of the products is also discussed in this paper.

Supporting Information