Facile Synthesis of N-Substituted Benzimidazoles

Abstract

A particularly mild and efficient one-pot synthesis of N-substituted benzimidazole derivatives was developed. 2-Fluoro-5-nitrophenylisocyanide reacts with a diverse set of primary amines to afford the respective products in moderate to very good yield (35–95%; 20 examples).

Key words

isocyanides - nucleophilic aromatic substitution - benzimidazole

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