Synthesis of Chiral Phosphorous and Phosphoric Acid Derivatives from the Lignans Matairesinol and Conidendrin

Abstract

Methods for the preparation of phosphites and phosphates from chiral diols based on lignan backbones were developed. Four novel phosphites and one phosphate were synthesized and characterized. Sterically hindered diols showed diastereoselectivity in formations of phosphites, whereas non-hindered diols showed no selectivity.

Key words

lignan - matairesinol - conidendrin - chiral 1,4-diols - chiral phosphites - chiral phosphates - chiral pool

• References and Notes

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