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Synlett 2016; 27(16): 2314-2326
DOI: 10.1055/s-0035-1562784
DOI: 10.1055/s-0035-1562784
account
Introduction of Functionalized Difluoromethylated Building Blocks Mediated or Catalyzed by Copper
Further Information
Publication History
Received: 02 June 2016
Accepted after revision: 17 June 2016
Publication Date:
20 July 2016 (online)
Abstract
This account summarizes our recent progress on the copper-catalyzed direct introduction of functionalized difluoromethylated building blocks, and more particularly, the CF2CO2Et motif. We also discuss how this work led us to develop new copper-mediated methodologies to introduce the CF2PO(OR)2 motif, a valuable phosphate bioisostere.
1 Introduction
2 Copper-Catalyzed Introduction of the CF2CO2Et Residue
3 New Developments Toward the Introduction of the CF2PO(OEt)2 Motif
4 Conclusion and Outlook
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For recent reviews, see:
For recent reviews, see:
For related papers from our group reporting the use of BrCF2CO2Et, see:
For selected examples, see:
For selected references from our group, see:
For selected examples, see:
For examples of α-selectivity, see:
For examples and discussion regarding the α/β selectivity, see:
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