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Synthesis 2016; 48(23): 4246-4252
DOI: 10.1055/s-0035-1562788
DOI: 10.1055/s-0035-1562788
paper
Ultrasound-Promoted Synthesis of 4-Pyrimidinols and Their Tosyl Derivatives
Further Information
Publication History
Received: 15 June 2016
Accepted after revision: 27 June 2016
Publication Date:
17 August 2016 (online)
Abstract
Ultrasound irradiation promoted the cyclocondensation of β-keto esters and amidines in good to excellent yields to form sixteen highly substituted 4-pyrimidinols. Tosylation of these compounds, in another ultrasound-promoted conversion, formed 4-pyrimidyl tosylates in high yields. The use of the developed protocol as an alternative route to 4-arylpyrimidines was illustrated with three examples of the Suzuki–Miyaura cross-coupling of the prepared tosylates with phenylboronic acid.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1562788.
- Supporting Information
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