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Synthesis 2016; 48(23): 4295-4299
DOI: 10.1055/s-0035-1562789
DOI: 10.1055/s-0035-1562789
paper
An Improved Synthesis of Multi-Substituted Pyrazines under Catalyst- and Solvent-Free Conditions
Further Information
Publication History
Received: 03 May 2016
Accepted after revision: 27 June 2016
Publication Date:
25 August 2016 (online)
Abstract
A one-pot pseudo four-component reaction between a variety of 2-hydroxy-1,2-diarylethanone derivatives and ammonium acetate or amines has been developed to synthesize substituted pyrazines under catalyst-free and solvent-free conditions. This procedure provides a synthetic method to access pyrazine derivatives in excellent yields under green conditions.
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