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Semin Thromb Hemost 2016; 42(02): 112-117
DOI: 10.1055/s-0035-1564832
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Relative Risks of Thrombosis and Bleeding in Different ABO Blood Groups

Massimo Franchini
1   Department of Hematology and Transfusion Medicine, Carlo Poma Hospital, Mantova, Italy
,
Giuseppe Lippi
2   Section of Clinical Biochemistry, University of Verona, Verona, Italy
› Author Affiliations
Further Information

Publication History

Publication Date:
30 December 2015 (online)

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Abstract

The ABO blood group system is composed of complex carbohydrate molecules (i.e., the A, B, and H determinants) that are widely expressed on the surface of red blood cells and in a variety of other cell and tissues. Along with their pivotal role in transfusion and transplantation medicine, the ABO antigens participate in many other physiological processes and, in particular, are important determinants of von Willebrand factor and factor VIII circulating plasma levels. The precise influence of the ABO system on hemostasis has led the way to the investigation of a putative implication in the risk of developing cardiovascular disorders. Along with the underlying molecular mechanisms, the current knowledge on the role of ABO blood group antigens in both the thrombotic and hemorrhagic risk will be summarized in this narrative review.

Keywords

ABO blood group - arterial thrombosis - venous thromboembolism - bleeding
 

  • References

  • 1 Storry JR, Olsson ML. The ABO blood group system revisited: a review and update. Immunohematology 2009; 25 (2) 48-59
    PubMedGoogle Scholar
  • 2 Yamamoto F. Review: ABO blood group system—ABH oligosaccharide antigens, anti-A and anti-B, A and B glycosyltransferases, and ABO genes. Immunohematology 2004; 20 (1) 3-22
    PubMedGoogle Scholar
  • 3 Yamamoto F, Cid E, Yamamoto M, Blancher A. ABO research in the modern era of genomics. Transfus Med Rev 2012; 26 (2) 103-118
    CrossrefPubMedGoogle Scholar
  • 4 Lowe JB. The blood group-specific human glycosyltransferases. Baillieres Clin Haematol 1993; 6 (2) 465-492
    CrossrefPubMedGoogle Scholar
  • 5 Eastlund T. The histo-blood group ABO system and tissue transplantation. Transfusion 1998; 38 (10) 975-988
    PubMedGoogle Scholar
  • 6 Franchini M, Favaloro EJ, Targher G, Lippi G. ABO blood group, hypercoagulability, and cardiovascular and cancer risk. Crit Rev Clin Lab Sci 2012; 49 (4) 137-149
    CrossrefPubMedGoogle Scholar
  • 7 Liumbruno GM, Franchini M. Beyond immunohaematology: the role of the ABO blood group in human diseases. Blood Transfus 2013; 11 (4) 491-499
    PubMedGoogle Scholar
  • 8 Franchini M, Liumbruno GM. ABO blood group: old dogma, new perspectives. Clin Chem Lab Med 2013; 51 (8) 1545-1553
    PubMedGoogle Scholar
  • 9 Franchini M, Mannucci PM. ABO blood group and thrombotic vascular disease. Thromb Haemost 2014; 112 (6) 1103-1109
    Article in Thieme ConnectPubMedGoogle Scholar
  • 10 Anstee DJ. The relationship between blood groups and disease. Blood 2010; 115 (23) 4635-4643
    CrossrefPubMedGoogle Scholar
  • 11 Dentali F, Sironi AP, Ageno W , et al. Non-O blood type is the commonest genetic risk factor for VTE: results from a meta-analysis of the literature. Semin Thromb Hemost 2012; 38 (5) 535-548
    Article in Thieme ConnectPubMedGoogle Scholar
  • 12 Dentali F, Sironi AP, Ageno W, Crestani S, Franchini M. ABO blood group and vascular disease: an update. Semin Thromb Hemost 2014; 40 (1) 49-59
    PubMedGoogle Scholar
  • 13 Dentali F, Sironi AP, Ageno W , et al. Relationship between ABO blood group and hemorrhage: a systematic literature review and meta-analysis. Semin Thromb Hemost 2013; 39 (1) 72-82
    Article in Thieme ConnectPubMedGoogle Scholar
  • 14 Jenkins PV, O'Donnell JS. ABO blood group determines plasma von Willebrand factor levels: a biologic function after all?. Transfusion 2006; 46 (10) 1836-1844
    CrossrefPubMedGoogle Scholar
  • 15 Campos M, Sun W, Yu F , et al. Genetic determinants of plasma von Willebrand factor antigen levels: a target gene SNP and haplotype analysis of ARIC cohort. Blood 2011; 117 (19) 5224-5230
    CrossrefPubMedGoogle Scholar
  • 16 Campos M, Buchanan A, Yu F , et al. Influence of single nucleotide polymorphisms in factor VIII and von Willebrand factor genes on plasma factor VIII activity: the ARIC Study. Blood 2012; 119 (8) 1929-1934
    CrossrefPubMedGoogle Scholar
  • 17 Casari C, Lenting PJ, Wohner N, Christophe OD, Denis CV. Clearance of von Willebrand factor. J Thromb Haemost 2013; 11 (Suppl. 01) 202-211
    CrossrefPubMedGoogle Scholar
  • 18 Paré G, Chasman DI, Kellogg M , et al. Novel association of ABO histo-blood group antigen with soluble ICAM-1: results of a genome-wide association study of 6,578 women. PLoS Genet 2008; 4 (7) e1000118
    CrossrefPubMedGoogle Scholar
  • 19 Karakas M, Baumert J, Kleber ME , et al. A variant in the ABO gene explains the variation in soluble E-selectin levels-results from dense genotyping in two independent populations. PLoS ONE 2012; 7 (12) e51441
    CrossrefPubMedGoogle Scholar
  • 20 Paterson AD, Lopes-Virella MF, Waggott D , et al; Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group. Genome-wide association identifies the ABO blood group as a major locus associated with serum levels of soluble E-selectin. Arterioscler Thromb Vasc Biol 2009; 29 (11) 1958-1967
    CrossrefPubMedGoogle Scholar
  • 21 Chen Y, Chen C, Ke X , et al. Analysis of circulating cholesterol levels as a mediator of an association between ABO blood group and coronary heart disease. Circ Cardiovasc Genet 2014; 7 (1) 43-48
    PubMedGoogle Scholar
  • 22 Medalie JH, Levene C, Papier C , et al. Blood groups, myocardial infarction and angina pectoris among 10,000 adult males. N Engl J Med 1971; 285 (24) 1348-1353
    CrossrefPubMedGoogle Scholar
  • 23 Whincup PH, Cook DG, Phillips AN, Shaper AG. ABO blood group and ischaemic heart disease in British men. BMJ 1990; 300 (6741) 1679-1682
    CrossrefPubMedGoogle Scholar
  • 24 Jager A, van Hinsbergh VW, Kostense PJ , et al. von Willebrand factor, C-reactive protein, and 5-year mortality in diabetic and nondiabetic subjects: the Hoorn Study. Arterioscler Thromb Vasc Biol 1999; 19 (12) 3071-3078
    CrossrefPubMedGoogle Scholar
  • 25 Carpeggiani C, Coceani M, Landi P, Michelassi C, L'abbate A. ABO blood group alleles: A risk factor for coronary artery disease. An angiographic study. Atherosclerosis 2010; 211 (2) 461-466
    CrossrefPubMedGoogle Scholar
  • 26 Etemadi A, Kamangar F, Islami F , et al. Mortality and cancer in relation to ABO blood group phenotypes in the Golestan Cohort Study. BMC Med 2015; 13: 8
    CrossrefPubMedGoogle Scholar
  • 27 Franchini M, Lippi G. The intriguing relationship between the ABO blood group, cardiovascular disease, and cancer. BMC Med 2015; 13: 7
    CrossrefPubMedGoogle Scholar
  • 28 Pourafkari L, Ghaffari S, Ahmadi M, Tajlil A, Nader ND. Association of ABO blood types with the risk of in-stent restenosis. Perfusion 2015; 30 (6) 507-513
    CrossrefPubMedGoogle Scholar
  • 29 Wiggins KL, Smith NL, Glazer NL , et al. ABO genotype and risk of thrombotic events and hemorrhagic stroke. J Thromb Haemost 2009; 7 (2) 263-269
    CrossrefPubMedGoogle Scholar
  • 30 Hanson E, Karlsson S, Jood K, Nilsson S, Blomstrand C, Jern C. No evidence for an association between ABO blood group and overall ischemic stroke or any of the major etiologic subtypes. Thromb Res 2012; 130 (3) 339-342
    CrossrefPubMedGoogle Scholar
  • 31 Reilly MP, Li M, He J , et al; Myocardial Infarction Genetics Consortium; Wellcome Trust Case Control Consortium. Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies. Lancet 2011; 377 (9763) 383-392
    CrossrefPubMedGoogle Scholar
  • 32 Williams FM, Carter AM, Hysi PG , et al; EuroCLOT Investigators; Wellcome Trust Case Control Consortium 2; MOnica Risk, Genetics, Archiving and Monograph; MetaStroke; International Stroke Genetics Consortium. Ischemic stroke is associated with the ABO locus: the EuroCLOT study. Ann Neurol 2013; 73 (1) 16-31
    CrossrefPubMedGoogle Scholar
  • 33 Dichgans M, Malik R, König IR , et al; METASTROKE Consortium; CARDIoGRAM Consortium; C4D Consortium; International Stroke Genetics Consortium. Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants. Stroke 2014; 45 (1) 24-36
    CrossrefPubMedGoogle Scholar
  • 34 Wu O, Bayoumi N, Vickers MA, Clark P. ABO(H) blood groups and vascular disease: a systematic review and meta-analysis. J Thromb Haemost 2008; 6 (1) 62-69
    PubMedGoogle Scholar
  • 35 He M, Wolpin B, Rexrode K , et al. ABO blood group and risk of coronary heart disease in two prospective cohort studies. Arterioscler Thromb Vasc Biol 2012; 32 (9) 2314-2320
    CrossrefPubMedGoogle Scholar
  • 36 Schunkert H, König IR, Kathiresan S , et al; Cardiogenics; CARDIoGRAM Consortium. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet 2011; 43 (4) 333-338
    CrossrefPubMedGoogle Scholar
  • 37 Yang N, Zhang B, Xie L , et al. The association baseline NIH Stroke Scale score with ABO blood-subtypes in young patients with acute ischemic stroke. Atherosclerosis 2014; 236 (1) 144-149
    CrossrefPubMedGoogle Scholar
  • 38 Gong P, Luo SH, Li XL , et al. Relation of ABO blood groups to the severity of coronary atherosclerosis: an Gensini score assessment. Atherosclerosis 2014; 237 (2) 748-753
    CrossrefPubMedGoogle Scholar
  • 39 Dick W, Schneider W, Brockmueller K, Mayer W. Interrelations of thrombo-embolic diseases and blood group distribution. Thromb Diath Haemorrh 1963; 143: 472-474
    PubMedGoogle Scholar
  • 40 Koster T, Blann AD, Briët E, Vandenbroucke JP, Rosendaal FR. Role of clotting factor VIII in effect of von Willebrand factor on occurrence of deep-vein thrombosis. Lancet 1995; 345 (8943) 152-155
    CrossrefPubMedGoogle Scholar
  • 41 Wautrecht JC, Galle C, Motte S, Dereume JP, Dramaix M. The role of ABO blood groups in the incidence of deep vein thrombosis. Thromb Haemost 1998; 79 (3) 688-689
    PubMedGoogle Scholar
  • 42 Ohira T, Cushman M, Tsai MY , et al. ABO blood group, other risk factors and incidence of venous thromboembolism: the Longitudinal Investigation of Thromboembolism Etiology (LITE). J Thromb Haemost 2007; 5 (7) 1455-1461
    CrossrefPubMedGoogle Scholar
  • 43 El-Galaly TC, Kristensen SR, Overvad K, Steffensen R, Tjønneland A, Severinsen MT. Interaction between blood type, smoking and factor V Leiden mutation and risk of venous thromboembolism: a Danish case-cohort study. J Thromb Haemost 2012; 10 (10) 2191-2193
    CrossrefPubMedGoogle Scholar
  • 44 Spiezia L, Campello E, Bon M , et al. ABO blood groups and the risk of venous thrombosis in patients with inherited thrombophilia. Blood Transfus 2013; 11 (2) 250-253
    PubMedGoogle Scholar
  • 45 Wolpin BM, Kabrhel C, Varraso R , et al. Prospective study of ABO blood type and the risk of pulmonary embolism in two large cohort studies. Thromb Haemost 2010; 104 (5) 962-971
    Article in Thieme ConnectPubMedGoogle Scholar
  • 46 Gándara E, Kovacs MJ, Kahn SR , et al. Non-OO blood type influences the risk of recurrent venous thromboembolism. A cohort study. Thromb Haemost 2013; 110 (6) 1172-1179
    Article in Thieme ConnectPubMedGoogle Scholar
  • 47 Dentali F, Di Minno MN, Turato S , et al. Role of ABO blood group and of other risk factors on the presence of residual vein obstruction after deep-vein thrombosis. Thromb Res 2014; 134 (2) 264-267
    CrossrefPubMedGoogle Scholar
  • 48 Trégouët DA, Heath S, Saut N , et al. Common susceptibility alleles are unlikely to contribute as strongly as the FV and ABO loci to VTE risk: results from a GWAS approach. Blood 2009; 113 (21) 5298-5303
    CrossrefPubMedGoogle Scholar
  • 49 Gill JC, Endres-Brooks J, Bauer PJ, Marks Jr WJ, Montgomery RR. The effect of ABO blood group on the diagnosis of von Willebrand disease. Blood 1987; 69 (6) 1691-1695
    CrossrefPubMedGoogle Scholar
  • 50 Horwich L, Evans DA, McConnell RB, Donohoe WT. ABO blood groups in gastric bleeding. Gut 1966; 7 (6) 680-685
    CrossrefPubMedGoogle Scholar
  • 51 Evans DA, Horwich L, McConnell RB, Bullen MF. Influence of the ABO blood groups and secretor status on bleeding and on perforation of duodenal ulcer. Gut 1968; 9 (3) 319-322
    CrossrefPubMedGoogle Scholar
  • 52 Viskum K. Long-term survival of patients with gastrointestinal haemorrhage with special reference to the ABO blood groups. Scand J Gastroenterol 1972; 7 (1) 55-63
    CrossrefPubMedGoogle Scholar
  • 53 Bayan K, Tüzün Y, Yilmaz S, Dursun M, Canoruc F. Clarifying the relationship between ABO/Rhesus blood group antigens and upper gastrointestinal bleeding. Dig Dis Sci 2009; 54 (5) 1029-1034
    CrossrefPubMedGoogle Scholar
  • 54 Reddy VM, Daniel M, Bright E, Broad SR, Moir AA. Is there an association between blood group O and epistaxis?. J Laryngol Otol 2008; 122 (4) 366-368
    PubMedGoogle Scholar
  • 55 Leonard DS, Fenton JE, Hone S. ABO blood type as a risk factor for secondary post-tonsillectomy haemorrhage. Int J Pediatr Otorhinolaryngol 2010; 74 (7) 729-732
    CrossrefPubMedGoogle Scholar
  • 56 Ionescu DA, Marcu I, Bicescu E. Cerebral thrombosis, cerebral haemorrhage, and ABO blood-groups. Lancet 1976; 1 (7954) 278-280
    PubMedGoogle Scholar
  • 57 Welsby IJ, Jones R, Pylman J , et al; Cardiothoracic Anesthesiology Research Endeavours (C.A.R.E.), Department of Anesthesiology, Duke University Medical Center. ABO blood group and bleeding after coronary artery bypass graft surgery. Blood Coagul Fibrinolysis 2007; 18 (8) 781-785
    CrossrefPubMedGoogle Scholar
  • 58 Franchini M, Crestani S, Frattini F, Mengoli C, Bonfanti C. Relationship between ABO blood group and bleeding complications in orally anticoagulated patients. J Thromb Haemost 2012; 10 (8) 1688-1691
    CrossrefPubMedGoogle Scholar
  • 59 Franchini M, Rossi C, Mengoli C , et al. O blood group is a risk factor for severe mucosal hemorrhage in orally anticoagulated patients. J Thromb Thrombolysis 2013; 36 (3) 358-360
    CrossrefPubMedGoogle Scholar
  • 60 Lippi G, Franchini M, Brocco G, Manzato F. Influence of the ABO blood type on the platelet function analyzer PFA-100. Thromb Haemost 2001; 85 (2) 369-370
    PubMedGoogle Scholar