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Semin Thromb Hemost 2016; 42(01): 075-086
DOI: 10.1055/s-0035-1564843
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Correlation between ABO Blood Group, and Conventional Hematological and Metabolic Parameters in Blood Donors

Massimo Franchini
1   Department of Hematology and Transfusion Medicine, Carlo Poma Hospital, Mantova, Italy
,
Carlo Mengoli
2   University of Padova, Padova, Italy
,
Enrico Capuzzo
1   Department of Hematology and Transfusion Medicine, Carlo Poma Hospital, Mantova, Italy
,
Isabella Terenziani
3   Laboratory, Carlo Poma Hospital, Mantova, Italy
,
Carlo Bonfanti
1   Department of Hematology and Transfusion Medicine, Carlo Poma Hospital, Mantova, Italy
,
Giuseppe Lippi
4   Laboratory of Clinical Chemistry and Hematology, Academic Hospital of Parma, Parma, Italy
› Institutsangaben
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Publikationsdatum:
23. November 2015 (online)

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Abstract

Background Although several studies have investigated and confirmed the existence of an association between ABO blood type and several human disorders, especially with cardiovascular disease, little is known on the physiological influence or association of ABO blood groups on basal levels of some conventional hematological and metabolic parameters.

Study Design and Methods A total number of 7,723 consecutive healthy blood donors underwent laboratory testing at the time of their first blood donation, which apart from ABO typing included assessment of alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transferase, total bilirubin, total cholesterol, high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), triglycerides, creatinine, iron, ferritin, uric acid, glucose, hemoglobin, and platelet count.

Results The most relevant finding was the identification of significantly higher values of total cholesterol and HDL-c in subjects with blood group A compared with those with O blood type, with the highest levels being observed in A1 subtype.

Conclusions The positive association between A blood type and plasma lipid levels supports its potential role in the pathogenesis of atherosclerosis and the clinical observations of increased vulnerability to cardiovascular disease of individuals with non-O blood groups.

Keywords

ABO blood groups - cholesterol - plasma lipids - cardiovascular disease - thrombosis
 

  • References

  • 1 Storry JR, Olsson ML. The ABO blood group system revisited: a review and update. Immunohematology 2009; 25 (2) 48-59
    PubMedGoogle Scholar
  • 2 Yamamoto F, Clausen H, White T, Marken J, Hakomori S. Molecular genetic basis of the histo-blood group ABO system. Nature 1990; 345 (6272) 229-233
    CrossrefPubMedGoogle Scholar
  • 3 Lowe JB. The blood group-specific human glycosyltransferases. Baillieres Clin Haematol 1993; 6 (2) 465-492
    CrossrefPubMedGoogle Scholar
  • 4 Franchini M, Liumbruno GM. ABO blood group: old dogma, new perspectives. Clin Chem Lab Med 2013; 51 (8) 1545-1553
    PubMedGoogle Scholar
  • 5 Franchini M, Mannucci PM. ABO blood group and thrombotic vascular disease. Thromb Haemost 2014; 112 (6) 1103-1109
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 6 Franchini M, Rossi C, Mengoli C , et al. ABO blood group and risk of coronary artery disease. J Thromb Thrombolysis 2013; 36 (3) 286-287
    CrossrefPubMedGoogle Scholar
  • 7 Anstee DJ. The relationship between blood groups and disease. Blood 2010; 115 (23) 4635-4643
    CrossrefPubMedGoogle Scholar
  • 8 Liumbruno GM, Franchini M. Beyond immunohaematology: the role of the ABO blood group in human diseases. Blood Transfus 2013; 11 (4) 491-499
    PubMedGoogle Scholar
  • 9 Franchini M, Favaloro EJ, Targher G, Lippi G. ABO blood group, hypercoagulability, and cardiovascular and cancer risk. Crit Rev Clin Lab Sci 2012; 49 (4) 137-149
    CrossrefPubMedGoogle Scholar
  • 10 Franchini M, Lippi G. The intriguing relationship between the ABO blood group, cardiovascular disease, and cancer. BMC Med 2015; 13: 7
    CrossrefPubMedGoogle Scholar
  • 11 Chello M, Spadaccio C. ABO gene variants and increased risk of atherosclerosis. Atherosclerosis 2013; 228 (2) 327-328
    CrossrefPubMedGoogle Scholar
  • 12 Fagherazzi G, Gusto G, Clavel-Chapelon F, Balkau B, Bonnet F. ABO and Rhesus blood groups and risk of type 2 diabetes: evidence from the large E3N cohort study. Diabetologia 2015; 58 (3) 519-522
    CrossrefPubMedGoogle Scholar
  • 13 Jenkins PV, O'Donnell JS. ABO blood group determines plasma von Willebrand factor levels: a biologic function after all?. Transfusion 2006; 46 (10) 1836-1844
    CrossrefPubMedGoogle Scholar
  • 14 Paré G, Chasman DI, Kellogg M , et al. Novel association of ABO histo-blood group antigen with soluble ICAM-1: results of a genome-wide association study of 6,578 women. PLoS Genet 2008; 4 (7) e1000118
    CrossrefPubMedGoogle Scholar
  • 15 Karakas M, Baumert J, Kleber ME , et al. A variant in the ABO gene explains the variation in soluble E-selectin levels-results from dense genotyping in two independent populations. PLoS ONE 2012; 7 (12) e51441
    CrossrefPubMedGoogle Scholar
  • 16 Paterson AD, Lopes-Virella MF, Waggott D , et al; Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group. Genome-wide association identifies the ABO blood group as a major locus associated with serum levels of soluble E-selectin. Arterioscler Thromb Vasc Biol 2009; 29 (11) 1958-1967
    CrossrefPubMedGoogle Scholar
  • 17 Chen Y, Chen C, Ke X , et al. Analysis of circulating cholesterol levels as a mediator of an association between ABO blood group and coronary heart disease. Circ Cardiovasc Genet 2014; 7 (1) 43-48
    PubMedGoogle Scholar
  • 18 Etemadi A, Kamangar F, Islami F , et al. Mortality and cancer in relation to ABO blood group phenotypes in the Golestan Cohort Study. BMC Med 2015; 13: 8
    CrossrefPubMedGoogle Scholar
  • 19 Gillum RF. Blood groups, serum cholesterol, serum uric acid, blood pressure, and obesity in adolescents. J Natl Med Assoc 1991; 83 (8) 682-688
    PubMedGoogle Scholar
  • 20 Wong FL, Kodama K, Sasaki H, Yamada M, Hamilton HB. Longitudinal study of the association between ABO phenotype and total serum cholesterol level in a Japanese cohort. Genet Epidemiol 1992; 9 (6) 405-418
    CrossrefPubMedGoogle Scholar
  • 21 Schmitz G, Kaminski WE. ABCA2: a candidate regulator of neural transmembrane lipid transport. Cell Mol Life Sci 2002; 59 (8) 1285-1295
    CrossrefPubMedGoogle Scholar
  • 22 Teupser D, Baber R, Ceglarek U , et al. Genetic regulation of serum phytosterol levels and risk of coronary artery disease. Circ Cardiovasc Genet 2010; 3 (4) 331-339
    CrossrefPubMedGoogle Scholar
  • 23 Klop B, van de Geijn GJ, Bovenberg SA , et al. Erythrocyte-bound apolipoprotein B in relation to atherosclerosis, serum lipids and ABO blood group. PLoS ONE 2013; 8 (9) e75573
    CrossrefPubMedGoogle Scholar
  • 24 Wu O, Bayoumi N, Vickers MA, Clark P. ABO(H) blood groups and vascular disease: a systematic review and meta-analysis. J Thromb Haemost 2008; 6 (1) 62-69
    PubMedGoogle Scholar
  • 25 Dentali F, Sironi AP, Ageno W, Crestani S, Franchini M. ABO blood group and vascular disease: an update. Semin Thromb Hemost 2014; 40 (1) 49-59
    PubMedGoogle Scholar
  • 26 Fourel V, Gabastou JM, Desroys du Roure F, Ehrhardt N, Robert A. Influence of age, sex and ABO blood group on activated partial thromboplastin time. Haemostasis 1993; 23 (6) 321-326
    PubMedGoogle Scholar
  • 27 Lippi G, Montagnana M, Franchini M, Favaloro EJ, Targher G. The paradoxical relationship between serum uric acid and cardiovascular disease. Clin Chim Acta 2008; 392 (1–2) 1-7
    CrossrefPubMedGoogle Scholar
  • 28 Koley S. The distribution of the ABO blood types in patients with diabetes mellitus. Anthropologist 2008; 10 (2) 129-132
    PubMedGoogle Scholar
  • 29 Qi L, Cornelis MC, Kraft P , et al. Genetic variants in ABO blood group region, plasma soluble E-selectin levels and risk of type 2 diabetes. Hum Mol Genet 2010; 19 (9) 1856-1862
    CrossrefPubMedGoogle Scholar
  • 30 Egawa N, Lin Y, Tabata T , et al. ABO blood type, long-standing diabetes, and the risk of pancreatic cancer. World J Gastroenterol 2013; 19 (16) 2537-2542
    CrossrefPubMedGoogle Scholar
  • 31 Bener A, Yousafzai MT. The distribution of the ABO blood groups among diabetes mellitus patients in Qatar. Niger J Clin Pract 2014; 17 (5) 565-568
    CrossrefPubMedGoogle Scholar
  • 32 Moinzadeh F, Najafabady GM, Toghiani A. Type 2 diabetes mellitus and ABO/Rh blood groups. J Res Med Sci 2014; 19 (4) 382
    PubMedGoogle Scholar
  • 33 Bonakdaran S, Kharaqani B. Association of serum uric acid and metabolic syndrome in type 2 diabetes. Curr Diabetes Rev 2014; 10 (2) 113-117
    CrossrefPubMedGoogle Scholar