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Exp Clin Endocrinol Diabetes 2016; 124(01): 49-54
DOI: 10.1055/s-0035-1565093
Article
© Georg Thieme Verlag KG Stuttgart · New York

Biomarkers in Obesity: Serum Myeloperoxidase and Traditional Cardiac Risk Parameters

D. C. K. Borato
1   Department of Clinical and Toxicological Analysis, State University of Ponta Grossa – UEPG, Uvaranas Campus, Ponta Grossa – PR, Brazil
,
G. C. Parabocz
1   Department of Clinical and Toxicological Analysis, State University of Ponta Grossa – UEPG, Uvaranas Campus, Ponta Grossa – PR, Brazil
,
J. T. Ribas
1   Department of Clinical and Toxicological Analysis, State University of Ponta Grossa – UEPG, Uvaranas Campus, Ponta Grossa – PR, Brazil
,
H. P. Netto
1   Department of Clinical and Toxicological Analysis, State University of Ponta Grossa – UEPG, Uvaranas Campus, Ponta Grossa – PR, Brazil
,
F. C. Erdmann
1   Department of Clinical and Toxicological Analysis, State University of Ponta Grossa – UEPG, Uvaranas Campus, Ponta Grossa – PR, Brazil
,
L. D. Wiecheteck
1   Department of Clinical and Toxicological Analysis, State University of Ponta Grossa – UEPG, Uvaranas Campus, Ponta Grossa – PR, Brazil
,
F. A. Manente
1   Department of Clinical and Toxicological Analysis, State University of Ponta Grossa – UEPG, Uvaranas Campus, Ponta Grossa – PR, Brazil
,
L. R. de Almeida Mello
1   Department of Clinical and Toxicological Analysis, State University of Ponta Grossa – UEPG, Uvaranas Campus, Ponta Grossa – PR, Brazil
,
C. Belló
1   Department of Clinical and Toxicological Analysis, State University of Ponta Grossa – UEPG, Uvaranas Campus, Ponta Grossa – PR, Brazil
,
F. André dos Santos
2   Department of Dentistry, State University of Ponta Grossa – UEPG, Uvaranas Campus, Ponta Grossa – PR, Brazil
,
L. M. Borba
1   Department of Clinical and Toxicological Analysis, State University of Ponta Grossa – UEPG, Uvaranas Campus, Ponta Grossa – PR, Brazil
,
J. C. R. Vellosa
1   Department of Clinical and Toxicological Analysis, State University of Ponta Grossa – UEPG, Uvaranas Campus, Ponta Grossa – PR, Brazil
› Author Affiliations
Further Information

Publication History

received 10 May 2015
first decision 02 October 2015

accepted 12 October 2015

Publication Date:
21 January 2016 (online)

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Abstract

Background: Chronic low-grade inflammation, combined with traditional cardiovascular risk factors, is common in obesity, providing systemic inflammation that is associated with increased cardiovascular risk. Studies have shown serum mieloperoxidase as a potential biomarker and its clinical applicability for evaluating cardiovascular risk. This study aimed to evaluate the MPO in obese individuals, with or without systemic inflammation and potential cardiovascular risk, as well as correlating MPO with some classic cardiovascular risk parameters.

Methods: Inflammatory and cardiovascular risk markers, as well as different biochemical and hematological laboratory parameters, were analyzed. The volunteers were divided into 3 groups according to the presence (hs-CRP>3 mg/L) or absence (hs-CRP<3 mg/L) of systemic inflammation and possible cardiovascular risk.

Results: MPO was significantly increased (p<0.05) in the obese individuals with systemic inflammation. A significant increase (p<0.05) in the following biochemical parameters: glucose, HbA1c, triglycerides, non-HDL, TG/HDL was observed, and a significant decrease (p<0.01) in HDL was observed. Significant increases in the counts of total leukocytes, neutrophils and monocytes (p<0.01), as well as elevated blood pressure (p<0.05), were observed in the group of obese individuals with systemic inflammation. Serum MPO levels were correlated with classic proinflammatory and cardiovascular risk parameters.

Conclusions: High serum levels of MPO were observed in obese individuals with hs-CRP above 3 mg/L, which is a classic biomarker for inflammation and cardiovascular risk, suggesting the potential role of MPO in clinical applicability for cardiovascular disease in this population. However, considering that inflammation in obesity appears to manifest as a non-classical mechanism, further studies are necessary to elucidate the role of MPO in cardiovascular events in the population with obesity.

Key words

inflammation - cardiovascular risk - obesity - myeloperoxidase
 

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