Elevated Serum Pentosidine and Decreased Serum IGF-I Levels are Associated with Loss of Muscle Mass in Postmenopausal Women with Type 2 Diabetes Mellitus

K. Tanaka; I. Kanazawa; T. Sugimoto

doi:10.1055/s-0035-1565103

Experimental and Clinical Endocrinology & Diabetes, Inhaltsverzeichnis

Exp Clin Endocrinol Diabetes 2016; 124(03): 163-166
DOI: 10.1055/s-0035-1565103

Article

Elevated Serum Pentosidine and Decreased Serum IGF-I Levels are Associated with Loss of Muscle Mass in Postmenopausal Women with Type 2 Diabetes Mellitus

K. Tanaka

¹Department of Internal Medicine 1, Shimane University Faculty of Medicine, Izumo, Japan

,

I. Kanazawa

¹Department of Internal Medicine 1, Shimane University Faculty of Medicine, Izumo, Japan

,

T. Sugimoto

¹Department of Internal Medicine 1, Shimane University Faculty of Medicine, Izumo, Japan

› Institutsangaben

Abstract

Advanced glycation end-products (AGEs) play important roles in the progression of diabetic complications. Although sarcopenia is recently recognized as another complication associated with diabetes mellitus, its mechanism still remains unclear. In this study, we investigated the relationship between serum levels of pentosidine, which is one of AGEs, and insulin-like growth factor-I (IGF-I) vs. skeletal muscle mass by whole body dual-energy x-ray absorptiometry in 133 postmenopausal women with type 2 diabetes. Relative skeletal muscle mass index (RSMI) was calculated by following formula; appendicular skeletal muscle mass divided by height in meters squared. Simple correlation analyses showed that serum pentosidine levels were significantly and negatively correlated with muscle mass of legs (r=−0.21, p=0.017) and RSMI (r=−0.18, p=0.022), and that IGF-I was significantly and positively correlated with muscle mass of arms and legs (r=0.23, p=0.008 and r=0.30, p=0.001, respectively) as well as RSMI (r=0.20, p=0.022). Moreover, after adjusting for age, duration of diabetes, serum creatinine, HbA1c, and IGF-I, pentosidine was significantly and negatively associated with RSMI (β=−0.27, p=0.018) and marginally with muscle mass of legs (β=−0.18, p=0.071). The associations between IGF-I and indices of muscle mass such as arms, legs and RSMI were still significant after additional adjustment for pentosidine (p=0.016, 0.019 and 0.021, respectively). These findings indicate that increased serum pentosidine and decreased IGF-I are independent risk factors for loss of muscle mass in postmenopausal women with type 2 diabetes.

Key words

pentosidine - skeletal muscle mass - sarcopenia - diabetes mellitus - IGF-I

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References
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