Download PDF
Exp Clin Endocrinol Diabetes 2016; 124(04): 225-229
DOI: 10.1055/s-0035-1565192
Article
© Georg Thieme Verlag KG Stuttgart · New York

Thyroid Hormone Withdrawal Further Exacerbates Oxidative Stress in Patients with Thyroid Carcinoma

K. Unluhizarci
1   Department of Endocrinology, Erciyes University Medical School, Kayseri, Turkey
,
A. Kiris
1   Department of Endocrinology, Erciyes University Medical School, Kayseri, Turkey
,
K. Kose
2   Biochemistry, Erciyes University Medical School, Kayseri, Turkey
,
E. Tanrikulu
2   Biochemistry, Erciyes University Medical School, Kayseri, Turkey
,
Z. Karaca
1   Department of Endocrinology, Erciyes University Medical School, Kayseri, Turkey
,
F. Tanriverdi
1   Department of Endocrinology, Erciyes University Medical School, Kayseri, Turkey
,
F. Kelestimur
1   Department of Endocrinology, Erciyes University Medical School, Kayseri, Turkey
› Author Affiliations
Further Information

Publication History

received 01 February 2015
first decision 06 October 2015

accepted 31 October 2015

Publication Date:
29 January 2016 (online)

Also available at
    Permissions and Reprints

Abstract

Purpose: Hypothyroidism has profound effects on multiple organs and systems including cellular oxidative damage. Thus, we aimed to investigate the effects of acute hypothyroidism on oxidative stress in patients with differentiated thyroid carcinoma (DTC).

Patients: 33 patients with DTC were involved in the study. 23 healthy subjects matched for age and body mass index (BMI) served as control group. Fasting blood sample was obtained for the determination of blood chemistry, lipids, myeloperoxidase (MPO) activity, total lipid hydroperoxide (LHP), pyrrolized protein, protein carbonyl compounds (PCC), advanced oxidation protein products (AOPP) and thiol levels before and after thyroid hormone withdrawal (THW) in patients with DTC.

Results: MPO activity, total LHP, pyrrolized protein, PCC and AOPP levels were significantly higher, but thiol levels were significantly lower in patients with DTC while on L-thyroxine treatment than those of healthy subjects. At acute hypothyroid status after THW, MPO activity, total LHP, pyrrolized protein, PCC and AOPP levels further increased, thiol levels further decreased in patients with DTC as compared to healthy subjects and to their on L-thyroxine treatment period.

Conclusions: This study showed an increased oxidative stress in patients with DTC which is further exacerbated with acute hypothyroidism upon THW. This situation may have treatment implications such as antioxidant therapy, at least during THW.

Key words

thyroid hormone withdrawal - hypothyroidism - oxidative stress
 

  • References

  • 1 Akinci M, Kosova F, Cetin B et al. Oxidant/antioxidant balance in patients with thyroid cancer. Acta Cirurgica Brasileira 2008; 23: 551-554
    CrossrefPubMedGoogle Scholar
  • 2 Antunes TT, Gagnon AM, Bell A et al. Thyroid-stimulating hormone stimulates interleukin-6 release from 3T3-L1 adipocytes through a cAMP-protein kinase A pathway. Obes Res 2005; 13: 2066-2071
    CrossrefPubMedGoogle Scholar
  • 3 Baskol G, Atmaca H, Tanriverdi F et al. Oxidative stress and enzymtatic antioxidant status in patients with hypothyroidism before and after treatment. Exp Clin Endocrinol Diabetes 2007; 115: 522-526
    Article in Thieme ConnectPubMedGoogle Scholar
  • 4 Bradley PP, Priebat DA, Christensen RD et al. Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J Invest Dermatol 1982; 78: 206-269
    CrossrefPubMedGoogle Scholar
  • 5 Cetinkaya A, Kurutas EB, Buyukmese MA et al. Levels of malondialdehyde and superoxide dismutase in subclinical hyperthyroidism. Mediators Inflamm 2005; 24: 57-59
    PubMedGoogle Scholar
  • 6 Cooper DS, Doherty GM, Haugen BR et al. Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. J Clin Endocrinol Metab 2009; 19: 1167-1214
    PubMedGoogle Scholar
  • 7 Dalle-Donne I, Giustarini D, Colombo R et al. Protein carbonylation in human diseases. Trend Mol Med 2003; 9: 169-176
    CrossrefPubMedGoogle Scholar
  • 8 Dardano A, Ghiadoni L, Plantinga Y et al. Recombinant human thyrotropin reduces endothelium-dependent vasodilation in patients monitored for differentiated thyroid carcinoma. J Clin Endocrinol Metab 2006; 91: 4175-4178
    CrossrefPubMedGoogle Scholar
  • 9 Dow KH, Ferrell BR, Anello C. Quality-of-life changes in patients with thyroid cancer after withdrawal of thyroid hormone therapy. Thyroid 1997; 7: 613-619
    CrossrefPubMedGoogle Scholar
  • 10 Duntas LH. Thyroid disease and lipids. Thyroid 2002; 12: 287-293
    CrossrefPubMedGoogle Scholar
  • 11 Duntas LH. Oxidants, antioxidants in physical exercise and relation to thyroid function. Horm Metab Res 2005; 37: 572-576
    Article in Thieme ConnectPubMedGoogle Scholar
  • 12 Duntas LH, Biondi B. Short-term hypothyroidism after Levothyroxine-withdrawal in patients with differentiated thyroid cancer: clinical and quality of life consequences. Eur J Endocrinol 2007; 156: 13-19
    CrossrefPubMedGoogle Scholar
  • 13 Erdamar H, Demirci H, Yaman H et al. The effect of hypothyroidism, hyperthyroidism, and their treatment on parameters of oxidative stress and antioxidant status. Clin Chemistry Lab Med 2008; 46: 1004-1010
    PubMedGoogle Scholar
  • 14 Gargouri B, Lassoued S, Ayadi W et al. Lipid peroxidation and antioxidant system in the tumor and in the blood of patients with nasopharyngeal carcinoma. Biol Trace Element Res 2009; 132: 27-34
    CrossrefPubMedGoogle Scholar
  • 15 Haribabu A, Reddy VS, Ch Pallavi et al. Evaluation of protein oxidation and its association with lipid peroxidation and thyrotropin levels in overt and subclinical hypothyroidism. Endocrine 2013; 44: 152-157
    CrossrefPubMedGoogle Scholar
  • 16 Hidalgo FJ, Alaiz M, Zamora R. A specthrophotometric method for the determination of proteins damaged by oxidized lipids. Anal Biochemistry 1998; 262: 129-136
    CrossrefPubMedGoogle Scholar
  • 17 Hu ML, Louie S, Cross CE et al. Antioxidant protection against hypochlorous acid in human plasma. J. Clin Lab Med 1993; 121: 257-262
    PubMedGoogle Scholar
  • 18 Karger S, Krause K, Gutknecht M et al. Oxidative stres in the thyroid-DNA damage and repair: Important mechanisms in the pathogenesis of thyroid tumors. Exp Clin Endocrinol Diabetes 2007; 115: P01-P026
    PubMedGoogle Scholar
  • 19 Konukoglu D, Ercan M, Hatemi H. Plasma viscosity in female patients with hypothyroidism: effects of oxidative stress and cholesterol. Clin Hemor Microcircul 2002; 27: 107-113
    PubMedGoogle Scholar
  • 20 Kosova F, Cetin B, Akinci M et al. Advanced oxidation protein products, ferrous oxidation in xylenol orange, and malondialdehyde levels in thyroid cancer. Ann Surg Oncol 2007; 149: 2616-2620
    PubMedGoogle Scholar
  • 21 Lassoued S, Mseddi M, Mnif F et al. A comparative study of the oxidative profile in Graves' disease, Hashimoto's thyroiditis, and papillary thyroid cancer. Biol Trace Element Res 2010; 138: 107-115
    CrossrefPubMedGoogle Scholar
  • 22 Martinez-Cruz F, Guerrero JM, Osuna C. Melatonin prevents the formation of pyrrolized proteins in human plasma induced by hydrogen peroxide. Neurosci Lett 2002; 326: 147-150
    CrossrefPubMedGoogle Scholar
  • 23 Mezosi E, Szabo J, Nagy EV et al. Nongenomic effect of thyroid hormone on free-radical production in human polymorphonuclear leukocytes. J Endocrinol 2005; 185: 121-129
    CrossrefPubMedGoogle Scholar
  • 24 Nanda N, Bobby Z, Hamide A. Association of thyroid stimulating hormone and coronary lipid risk factors with lipid peroxidation in hypothyroidism. Clin Chem Lab Med 2008; 46: 674-679
    PubMedGoogle Scholar
  • 25 Nourrooz-Zadeh J. Ferrous ion oxidation in presence of xylenol orange for detection of lipid hydroperoxides in plasma. Methods Enzymol 1999; 300: 58-62
    PubMedGoogle Scholar
  • 26 Reznick AZ, Packer L. Oxidative damage to proteins: spectrophotometric method for carbonyl assays. Methods Enzymol 1994; 233: 357-363
    PubMedGoogle Scholar
  • 27 Santi A, Duarte MM, Moresco RN et al. Association between thyroid hormones, lipids and oxidative stress biomarkers in overt hypothyroidism. Clin Chemistry Lab Med 2010; 48: 1635-1639
    PubMedGoogle Scholar
  • 28 Santi A, Duarte MM, de Menezes CC, Loro VL. Association of lipids with oxidative stress biomarkers in subclinical hypothyroidism. Intern J Endocrinol 2012; 2012: 856359 DOI: 10.1155/2012/856359.
    PubMedGoogle Scholar
  • 29 Wang HC, Dragoo J Zhou O et al. An intrinsic thyrotropin-mediated pathway of TNF-production by bone marrow cells. Blood 2003; 101: 119-123
    CrossrefPubMedGoogle Scholar
  • 30 Weiss SJ. Tissue destruction by neutrophils. N Engl J Med 1989; 320: 365-376
    CrossrefPubMedGoogle Scholar
  • 31 Witko-Sarsat V, Friedlander M, Capeillère-Blandin C et al. Advanced oxidation protein products as a novel marker of oxidative stress in uremia. Kidney Int 1996; 49: 1304-1313
    CrossrefPubMedGoogle Scholar
  • 32 Yavuz DG, Yazici D, Toprak A et al. Exogenous subclinical hyperthyroidism impairs endothelial function in nodular goiter patients. Thyroid 2008; 18: 395-400
    CrossrefPubMedGoogle Scholar
  • 33 Yilmaz S, Ozan S, Benzer F et al. Oxidative damage and antioxidant enzyme activities in experimental hypothyroidism 2003; 21: 325-330
    PubMed