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Exp Clin Endocrinol Diabetes 2016; 124(04): 225-229
DOI: 10.1055/s-0035-1565192
Article
© Georg Thieme Verlag KG Stuttgart · New York

Thyroid Hormone Withdrawal Further Exacerbates Oxidative Stress in Patients with Thyroid Carcinoma

K. Unluhizarci
1   Department of Endocrinology, Erciyes University Medical School, Kayseri, Turkey
,
A. Kiris
1   Department of Endocrinology, Erciyes University Medical School, Kayseri, Turkey
,
K. Kose
2   Biochemistry, Erciyes University Medical School, Kayseri, Turkey
,
E. Tanrikulu
2   Biochemistry, Erciyes University Medical School, Kayseri, Turkey
,
Z. Karaca
1   Department of Endocrinology, Erciyes University Medical School, Kayseri, Turkey
,
F. Tanriverdi
1   Department of Endocrinology, Erciyes University Medical School, Kayseri, Turkey
,
F. Kelestimur
1   Department of Endocrinology, Erciyes University Medical School, Kayseri, Turkey
› Author Affiliations
Further Information

Publication History

received 01 February 2015
first decision 06 October 2015

accepted 31 October 2015

Publication Date:
29 January 2016 (online)

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Abstract

Purpose: Hypothyroidism has profound effects on multiple organs and systems including cellular oxidative damage. Thus, we aimed to investigate the effects of acute hypothyroidism on oxidative stress in patients with differentiated thyroid carcinoma (DTC).

Patients: 33 patients with DTC were involved in the study. 23 healthy subjects matched for age and body mass index (BMI) served as control group. Fasting blood sample was obtained for the determination of blood chemistry, lipids, myeloperoxidase (MPO) activity, total lipid hydroperoxide (LHP), pyrrolized protein, protein carbonyl compounds (PCC), advanced oxidation protein products (AOPP) and thiol levels before and after thyroid hormone withdrawal (THW) in patients with DTC.

Results: MPO activity, total LHP, pyrrolized protein, PCC and AOPP levels were significantly higher, but thiol levels were significantly lower in patients with DTC while on L-thyroxine treatment than those of healthy subjects. At acute hypothyroid status after THW, MPO activity, total LHP, pyrrolized protein, PCC and AOPP levels further increased, thiol levels further decreased in patients with DTC as compared to healthy subjects and to their on L-thyroxine treatment period.

Conclusions: This study showed an increased oxidative stress in patients with DTC which is further exacerbated with acute hypothyroidism upon THW. This situation may have treatment implications such as antioxidant therapy, at least during THW.

Key words

thyroid hormone withdrawal - hypothyroidism - oxidative stress
 

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