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Surg J (N Y) 2015; 01(01): e1-e15
DOI: 10.1055/s-0035-1565246
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

A Surgical View of Photodynamic Therapy in Oncology: A Review

K. Moghissi
1   The Yorkshire Laser Centre, Goole and District Hospital, Goole, East Yorkshire, United Kingdom
,
Kate Dixon
1   The Yorkshire Laser Centre, Goole and District Hospital, Goole, East Yorkshire, United Kingdom
,
Sally Gibbins
1   The Yorkshire Laser Centre, Goole and District Hospital, Goole, East Yorkshire, United Kingdom
› Author Affiliations
Further Information

Publication History

15 July 2015

25 August 2015

Publication Date:
15 October 2015 (online)

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Abstract

Clinical photodynamic therapy (PDT) has existed for over 30 years, and its scientific basis has been known and investigated for well over 100 years. The scientific foundation of PDT is solid and its application to cancer treatment for many common neoplastic lesions has been the subject of a huge number of clinical trials and observational studies. Yet its acceptance by many clinicians has suffered from its absence from the undergraduate and/or postgraduate education curricula of surgeons, physicians, and oncologists. Surgeons in a variety of specialties many with years of experience who are familiar with PDT bear witness in many thousands of publications to its safety and efficacy as well as to the unique role that it can play in the treatment of cancer with its targeting precision, its lack of collateral damage to healthy structures surrounding the treated lesions, and its usage within minimal access therapy. PDT is closely related to the fluorescence phenomenon used in photodiagnosis. This review aspires both to inform and to present the clinical aspect of PDT as seen by a surgeon.

Keywords

PDT in oncology - PDT for surgeons
 

  • References

  • 1 Raab O. Uber die Wirkung Fluorecierenden Stoffe auf Infusorien. Z Biol 1904; 30: 524-546
    PubMedGoogle Scholar
  • 2 von Tappeiner H, Odlabauer JA. Uber die Wirkung der photodynamischen (fluorescierenden) Stoffe auf Protozoen und Enzyne. Dtsch Arch Klin Med 1904; 80: 427-487
    PubMedGoogle Scholar
  • 3 von Tappeiner H, Jesionek H. Therapetische Versuche mit fluoreszierenden Stoffen. Munch Med Wochenschr 1903; 50: 2042-2044
    PubMedGoogle Scholar
  • 4 von Tappeiner JH. Zur Behand lung der Hautcarcinome mit fluoreszierenden Stoffen. Dtsch Arch Klin Med 1905; 82: 223-226
    PubMedGoogle Scholar
  • 5 Moghissi K, Stringer MR, Dixon K. Fluorescence photodiagnosis in clinical practice. Photodiagn Photodyn Ther 2008; 5 (4) 235-237
    CrossrefPubMedGoogle Scholar
  • 6 Krammer B, Malik Z, Pottier R, Stepp H. Principles of ALA-based FD. In: Pottier R, , et al, eds. Photodynamic Therapy with ALA: A Clinical Handbook. London, UK: RSC Publication; 2006: 51
    CrossrefGoogle Scholar
  • 7 Eljamel MS. Fluorescence image-guided surgery of brain tumors: explained step-by-step. Photodiagn Photodyn Ther 2008; 5 (4) 260-263
    CrossrefPubMedGoogle Scholar
  • 8 Lipson RL, Baldes EJ, Olsen AM. Hematoporphyrin derivative: a new aid for endoscopic detection of malignant disease. J Thorac Cardiovasc Surg 1961; 42: 623-629
    PubMedGoogle Scholar
  • 9 Lipson RL, Baldes EJ, Gray MJ. Hematoporphyrin derivative for detection and management of cancer. Cancer 1967; 20 (12) 2255-2257
    CrossrefPubMedGoogle Scholar
  • 10 Dougherty TJ, Kaufman JE, Goldfarb A, Weishaupt KR, Boyle D, Mittleman A. Photoradiation therapy for the treatment of malignant tumors. Cancer Res 1978; 38 (8) 2628-2635
    PubMedGoogle Scholar
  • 11 Kessel D, Dougherty TJ eds. Porphyrin Photosensitisers. New York, NY: Plenum Press; 1981
    Google Scholar
  • 12 Kennedy JC, Pottier RH. Endogenous protoporphyrin IX, a clinically useful photosensitizer for photodynamic therapy. J Photochem Photobiol B 1992; 14 (4) 275-292
    CrossrefPubMedGoogle Scholar
  • 13 Allison RR, Downie GH, Cuenca R, Hu XH, Childs CJ, Sibata CH. Photosensitizers in clinical PDT. Photodiagn Photodyn Ther 2004; 1 (1) 27-42
    CrossrefPubMedGoogle Scholar
  • 14 Mang TS. Lasers and light sources for PDT: past, present and future. Photodiagn Photodyn Ther 2004; 1 (1) 43-48
    CrossrefPubMedGoogle Scholar
  • 15 Castano AP, Demidova TN, Hamblin MR. Mechanisms in photodynamic therapy: part two-cellular signaling, cell metabolism and modes of cell death. Photodiagn Photodyn Ther 2005; 2 (1) 1-23
    CrossrefPubMedGoogle Scholar
  • 16 Oleinick NL, Nieminen AL, Chiu SM. Cell killing by photodynamic therapy. In: Hamblin MR, Mroz P, , eds. Advances in Photodynamic Therapy. Norwood, MA: Artec House; 2008: 115-133
    Google Scholar
  • 17 Allison RR, Moghissi K. Oncologic photodynamic therapy: clinical strategies that modulate mechanisms of action. Photodiagn Photodyn Ther 2013; 10 (4) 331-341
    CrossrefPubMedGoogle Scholar
  • 18 Firczuk M, Nowis D, Gołąb J. PDT-induced inflammatory and host responses. Photochem Photobiol Sci 2011; 10 (5) 653-663
    CrossrefPubMedGoogle Scholar
  • 19 Garg AD, Nowis D, Golab J, Agostinis P. Photodynamic therapy: illuminating the road from cell death towards anti-tumour immunity. Apoptosis 2010; 15 (9) 1050-1071
    CrossrefPubMedGoogle Scholar
  • 20 Ethirajan M, Saenz C, Gupta A , et al. Photosensitizers for photodynamic therapy and imaging. In: Hamblin MR, Pawet M, eds. Advances in Photodynamic Therapy. Norwood, MA: Artec House; 2008: 13-39
    Google Scholar
  • 21 Huang Z. Photodynamic therapy in China: over 25 years of unique clinical experience. Part One—History and domestic photosensitizers. Photodiagn Photodyn Ther 2006; 3 (1) 3-10
    CrossrefPubMedGoogle Scholar
  • 22 Sandell JL, Zhu TC. A review of in-vivo optical properties of human tissues and its impact on PDT. J Biophotonics 2011; 4 (11–12) 773-787
    CrossrefPubMedGoogle Scholar
  • 23 Fodor L, Elman M, Ullmann Y. Light tissue interaction. In: Aesthetic Applications of Intense Pulsed Light. London, UK: Springer-Verlag Publishers; 2011
    CrossrefGoogle Scholar
  • 24 Fayter D, Corbett M, Heirs M, Fox D, Eastwood A. A systematic review of photodynamic therapy in the treatment of pre-cancerous skin conditions, Barrett's oesophagus and cancers of the biliary tract, brain, head and neck, lung, oesophagus and skin. Health Technol Assess 2010; 14 (37) 1-288
    PubMedGoogle Scholar
  • 25 Gao F, Bai Y, Ma SR, Liu F, Li ZS. Systematic review: photodynamic therapy for unresectable cholangiocarcinoma. J Hepatobiliary Pancreat Sci 2010; 17 (2) 125-131
    CrossrefPubMedGoogle Scholar
  • 26 Wang I, Bauer B, Andersson-Engels S, Svanberg S, Svanberg K. Photodynamic therapy utilising topical delta-aminolevulinic acid in non-melanoma skin malignancies of the eyelid and the periocular skin. Acta Ophthalmol Scand 1999; 77 (2) 182-188
    CrossrefPubMedGoogle Scholar
  • 27 Loncaster J, Swindell R, Slevin F, Sheridan L, Allan D, Allan E. Efficacy of photodynamic therapy as a treatment for Gorlin syndrome-related basal cell carcinomas. Clin Oncol (R Coll Radiol) 2009; 21 (6) 502-508
    CrossrefPubMedGoogle Scholar
  • 28 Braathen LR, Szeimies RM, Basset-Seguin N , et al; International Society for Photodynamic Therapy in Dermatology. Guidelines on the use of photodynamic therapy for nonmelanoma skin cancer: an international consensus. International Society for Photodynamic Therapy in Dermatology, 2005. J Am Acad Dermatol 2007; 56 (1) 125-143
    CrossrefPubMedGoogle Scholar
  • 29 Morton C, Szeimies RM, Sidoroff A , et al. European Dermatology Forum Guidelines on topical photodynamic therapy. Eur J Dermatol 2015; ; June 12 (Epub ahead of print)
    PubMedGoogle Scholar
  • 30 Kennedy JC, Pottier RH, Pross DC. Photodynamic therapy with endogenous protoporphyrin IX: basic principles and present clinical experience. J Photochem Photobiol B 1990; 6 (1–2) 143-148
    CrossrefPubMedGoogle Scholar
  • 31 Piacquadio DJ, Chen DM, Farber HF , et al. Photodynamic therapy with aminolevulinic acid topical solution and visible blue light in the treatment of multiple actinic keratoses of the face and scalp: investigator-blinded, phase 3, multicenter trials. Arch Dermatol 2004; 140 (1) 41-46
    CrossrefPubMedGoogle Scholar
  • 32 Morton C, Horn M, Leman J , et al. Comparison of topical methyl aminolevulinate photodynamic therapy with cryotherapy or fluorouracil for treatment of squamous cell carcinoma in situ: results of a multicenter randomized trial. Arch Dermatol 2006; 142 (6) 729-735
    CrossrefPubMedGoogle Scholar
  • 33 Morton CA, Whitehurst C, Moseley H, McColl JH, Moore JV, Mackie RM. Comparison of photodynamic therapy with cryotherapy in the treatment of Bowen's disease. Br J Dermatol 1996; 135 (5) 766-771
    CrossrefPubMedGoogle Scholar
  • 34 Salim A, Leman JA, McColl JH, Chapman R, Morton CA. Randomized comparison of photodynamic therapy with topical 5-fluorouracil in Bowen's disease. Br J Dermatol 2003; 148 (3) 539-543
    CrossrefPubMedGoogle Scholar
  • 35 Basset-Seguin N, Ibbotson SH, Emtestam L , et al. Topical methyl aminolaevulinate photodynamic therapy versus cryotherapy for superficial basal cell carcinoma: a 5 year randomized trial. Eur J Dermatol 2008; 18 (5) 547-553
    PubMedGoogle Scholar
  • 36 Zeitouni NC, Shieh S, Oseroff AR. Laser and photodynamic therapy in the management of cutaneous malignancies. Clin Dermatol 2001; 19 (3) 328-338
    CrossrefPubMedGoogle Scholar
  • 37 Szeimies RM, Ibbotson S, Murrell DF , et al; Excilight Study Group. A clinical study comparing methyl aminolevulinate photodynamic therapy and surgery in small superficial basal cell carcinoma (8–20 mm), with a 12-month follow-up. J Eur Acad Dermatol Venereol 2008; 22 (11) 1302-1311
    CrossrefPubMedGoogle Scholar
  • 38 Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin 2011; 61 (2) 69-90
    CrossrefPubMedGoogle Scholar
  • 39 Keller GS, Doiron DR, Fischer GU. Photodynamic therapy in otorhinolaryngology-head and neck surgery. Arch Otolaryngol 1985; 111 (11) 758-761
    CrossrefPubMedGoogle Scholar
  • 40 Biel MA. Photodynamic therapy of head and neck cancers. Methods Mol Biol 2010; 635: 281-293
    PubMedGoogle Scholar
  • 41 von Beckerath MP, Reizenstein JA, Berner AL , et al. Outcome of primary treatment of early laryngeal malignancies using photodynamic therapy. Acta Otolaryngol 2014; 134 (8) 852-858
    CrossrefPubMedGoogle Scholar
  • 42 Ikeda H, Tobita T, Ohba S, Uehara M, Asahina I. Treatment outcome of Photofrin-based photodynamic therapy for T1 and T2 oral squamous cell carcinoma and dysplasia. Photodiagn Photodyn Ther 2013; 10 (3) 229-235
    CrossrefPubMedGoogle Scholar
  • 43 de Visscher SA, Melchers LJ, Dijkstra PU , et al. mTHPC-mediated photodynamic therapy of early stage oral squamous cell carcinoma: a comparison to surgical treatment. Ann Surg Oncol 2013; 20 (9) 3076-3082
    CrossrefPubMedGoogle Scholar
  • 44 Biel M. Advances in photodynamic therapy for the treatment of head and neck cancers. Lasers Surg Med 2006; 38 (5) 349-355
    CrossrefPubMedGoogle Scholar
  • 45 Allison RR, Sibata C, Gay H. PDT for cancers of the head and neck. Photodiagn Photodyn Ther 2009; 6 (1) 1-2
    CrossrefPubMedGoogle Scholar
  • 46 Green B, Cobb AR, Hopper C. Photodynamic therapy in the management of lesions of the head and neck. Br J Oral Maxillofac Surg 2013; 51 (4) 283-287
    CrossrefPubMedGoogle Scholar
  • 47 Graham EA, Singer JJ. Successful removal of an entire lung for carcinoma of the bronchus. JAMA 1933; 101: 13-17
    PubMedGoogle Scholar
  • 48 Kato H, Konaka C, Ono J , et al. Preoperative laser photodynamic therapy in combination with operation in lung cancer. J Thorac Cardiovasc Surg 1985; 90 (3) 420-429
    PubMedGoogle Scholar
  • 49 Okunaka T, Hiyoshi T, Furukawa K , et al. Lung cancers treated with photodynamic therapy and surgery. Diagn Ther Endosc 1999; 5 (3) 155-160
    CrossrefPubMedGoogle Scholar
  • 50 Ross Jr P, Grecula J, Bekaii-Saab T, Villalona-Calero M, Otterson G, Magro C. Incorporation of photodynamic therapy as an induction modality in non-small cell lung cancer. Lasers Surg Med 2006; 38 (10) 881-889
    CrossrefPubMedGoogle Scholar
  • 51 Akopov A, Rusanov A, Gerasin A, Kazakov N, Urtenova M, Chistyakov I. Preoperative endobronchial photodynamic therapy improves resectability in initially irresectable (inoperable) locally advanced non small cell lung cancer. Photodiagn Photodyn Ther 2014; 11 (3) 259-264
    CrossrefPubMedGoogle Scholar
  • 52 LoCicero III J, Metzdorff M, Almgren C. Photodynamic therapy in the palliation of late stage obstructing non-small cell lung cancer. Chest 1990; 98 (1) 97-100
    CrossrefPubMedGoogle Scholar
  • 53 Weimann TJ, Diaz-Jimenez JP, Moghissi K , et al. Photodynamic therapy (PDT) with Photofrin is effective in the palliation of obstructive endobronchial lung cancer; results of two randomized trials (abstract). Paper presented at: Proceedings of the 34th Annual Meeting of the American Society of Clinical Oncology; May 16–19, 1998; Los Angeles, CA
    PubMedGoogle Scholar
  • 54 Ono R, Ikeda S, Suemasu K. Hematoporphyrin derivative photodynamic therapy in roentgenographically occult carcinoma of the tracheobronchial tree. Cancer 1992; 69 (7) 1696-1701
    CrossrefPubMedGoogle Scholar
  • 55 Edell ES, Cortese DA. Photodynamic therapy in the management of early superficial squamous cell carcinoma as an alternative to surgical resection. Chest 1992; 102 (5) 1319-1322
    CrossrefPubMedGoogle Scholar
  • 56 Kato H. Photodynamic therapy for lung cancer—a review of 19 years' experience. J Photochem Photobiol B 1998; 42 (2) 96-99
    CrossrefPubMedGoogle Scholar
  • 57 Moghissi K, Dixon K, Thorpe JA, Stringer M, Oxtoby C. Photodynamic therapy (PDT) in early central lung cancer: a treatment option for patients ineligible for surgical resection. Thorax 2007; 62 (5) 391-395
    CrossrefPubMedGoogle Scholar
  • 58 McCaughan Jr JS, Williams TE. Photodynamic therapy for endobronchial malignant disease: a prospective fourteen-year study. J Thorac Cardiovasc Surg 1997; 114 (6) 940-946, discussion 946–947
    CrossrefPubMedGoogle Scholar
  • 59 Moghissi K, Dixon K, Stringer M, Freeman T, Thorpe A, Brown S. The place of bronchoscopic photodynamic therapy in advanced unresectable lung cancer: experience of 100 cases. Eur J Cardiothorac Surg 1999; 15 (1) 1-6
    PubMedGoogle Scholar
  • 60 Lam S, Macaulay C, Leriche JC, Ikeda N, Palcic B. Early localization of bronchogenic carcinoma. Diagn Ther Endosc 1994; 1 (2) 75-78
    CrossrefPubMedGoogle Scholar
  • 61 Horvath TA, Hirano T, Horvathova MD , et al. Autofluorescence (safe) bronchoscopy and p21/ki-67 immunostaining related to carcinogenesis. Photodiagn Photodyn Ther 2004; 1 (1) 13-22
    CrossrefPubMedGoogle Scholar
  • 62 Moghissi K, Dixon K, Stringer MR. Current indications and future perspective of fluorescence bronchoscopy: a review study. Photodiagn Photodyn Ther 2008; 5 (4) 238-246
    CrossrefPubMedGoogle Scholar
  • 63 Okunaka T, Kato H, Tsutsui H, Ishizumi T, Ichinose S, Kuroiwa Y. Photodynamic therapy for peripheral lung cancer. Lung Cancer 2004; 43 (1) 77-82
    CrossrefPubMedGoogle Scholar
  • 64 Moghissi K, Dixon K, Thorpe JA. A method for video-assisted thoracoscopic photodynamic therapy (VAT-PDT). Interact Cardiovasc Thorac Surg 2003; 2 (3) 373-375
    CrossrefPubMedGoogle Scholar
  • 65 DeMeester TR, Attwood SE, Smyrk TC, Therkildsen DH, Hinder RA. Surgical therapy in Barrett's esophagus. Ann Surg 1990; 212 (4) 528-540, discussion 540–542
    CrossrefPubMedGoogle Scholar
  • 66 Moghissi K, Sharpe DA, Pender D. Adenocarcinoma and Barrett's oesophagus. A clinico-pathological study. Eur J Cardiothorac Surg 1993; 7 (3) 126-131
    CrossrefPubMedGoogle Scholar
  • 67 Sujendran V, Sica G, Warren B, Maynard N. Oesophagectomy remains the gold standard for treatment of high-grade dysplasia in Barrett's oesophagus. Eur J Cardiothorac Surg 2005; 28 (5) 763-766
    CrossrefPubMedGoogle Scholar
  • 68 Downs-Kelly E, Mendelin JE, Bennett AE , et al. Poor interobserver agreement in the distinction of high-grade dysplasia and adenocarcinoma in pretreatment Barrett's esophagus biopsies. Am J Gastroenterol 2008; 103 (9) 2333-2340, quiz 2341
    CrossrefPubMedGoogle Scholar
  • 69 El Hallani S, Guillaud M, Korbelik J, Marginean EC. Evaluation of quantitative digital pathology in the assessment of Barrett esophagus-associated dysplasia. Am J Clin Pathol 2015; 144 (1) 151-164
    CrossrefPubMedGoogle Scholar
  • 70 Overholt BF, Wang KK, Burdick JS , et al; International Photodynamic Group for High-Grade Dysplasia in Barrett's Esophagus. Five-year efficacy and safety of photodynamic therapy with Photofrin in Barrett's high-grade dysplasia. Gastrointest Endosc 2007; 66 (3) 460-468
    CrossrefPubMedGoogle Scholar
  • 71 Oliphant Z, Snow A, Knight H, Barr H, Almond LM. Endoscopic resection with or without mucosal ablation of high grade dysplasia and early oesophageal adenocarcinoma—long term follow up from a regional UK centre. Int J Surg 2014; 12 (11) 1148-1150
    CrossrefPubMedGoogle Scholar
  • 72 Thorpe JA, Moghissi K. Photofrin PDT for Barrett's oesophagus with high-grade dysplasia. Photodiagn Photodyn Ther 2008; 5 (1) 36-37
    CrossrefPubMedGoogle Scholar
  • 73 American Cancer Society. Global Cancer Facts & Figures. 2nd ed. Atlanta, GA: American Cancer Society; 2011
    Google Scholar
  • 74 Moghissi K. Surgical resection for stage I cancer of the oesophagus and cardia. Br J Surg 1992; 79 (9) 935-937
    CrossrefPubMedGoogle Scholar
  • 75 Berry MF, Zeyer-Brunner J, Castleberry AW , et al. Treatment modalities for T1N0 esophageal cancers: a comparative analysis of local therapy versus surgical resection. J Thorac Oncol 2013; 8 (6) 796-802
    CrossrefPubMedGoogle Scholar
  • 76 McCaughan Jr JS, Guy JT, Hawley P , et al. Hematoporphyrin-derivative and photoradiation therapy of malignant tumors. Lasers Surg Med 1983; 3 (3) 199-209
    CrossrefPubMedGoogle Scholar
  • 77 McCaughan Jr JS, Ellison EC, Guy JT , et al. Photodynamic therapy for esophageal malignancy: a prospective twelve-year study. Ann Thorac Surg 1996; 62 (4) 1005-1009 , discussion 1009–1010
    CrossrefPubMedGoogle Scholar
  • 78 Moghissi K, Dixon K, Thorpe JA, Stringer M, Moore PJ. The role of photodynamic therapy (PDT) in inoperable oesophageal cancer. Eur J Cardiothorac Surg 2000; 17 (2) 95-100
    CrossrefPubMedGoogle Scholar
  • 79 Maier A, Tomaselli F, Gebhard F, Rehak P, Smolle J, Smolle-Jüttner FM. Palliation of advanced esophageal carcinoma by photodynamic therapy and irradiation. Ann Thorac Surg 2000; 69 (4) 1006-1009
    CrossrefPubMedGoogle Scholar
  • 80 Moghissi K. Where does photodynamic therapy fit in the esophageal cancer treatment jigsaw puzzle?. J Natl Compr Canc Netw 2012; 10 (Suppl. 02) S52-S55
    PubMedGoogle Scholar
  • 81 Sibille A, Lambert R, Souquet JC, Sabben G, Descos F. Long-term survival after photodynamic therapy for esophageal cancer. Gastroenterology 1995; 108 (2) 337-344
    CrossrefPubMedGoogle Scholar
  • 82 Moghissi K, Dixon K, Stringer M, Thorpe JA. Photofrin PDT for early stage oesophageal cancer: long term results in 40 patients and literature review. Photodiagn Photodyn Ther 2009; 6 (3–4) 159-166
    CrossrefPubMedGoogle Scholar
  • 83 Nakeeb A, Pitt HA, Sohn TA , et al. Cholangiocarcinoma. A spectrum of intrahepatic, perihilar, and distal tumors. Ann Surg 1996; 224 (4) 463-473 , discussion 473–475
    CrossrefPubMedGoogle Scholar
  • 84 McCaughan Jr JS, Mertens BF, Cho C, Barabash RD, Payton HW. Photodynamic therapy to treat tumors of the extrahepatic biliary ducts. A case report. Arch Surg 1991; 126 (1) 111-113
    CrossrefPubMedGoogle Scholar
  • 85 Ortner MA, Liebetruth J, Schreiber S , et al. Photodynamic therapy of nonresectable cholangiocarcinoma. Gastroenterology 1998; 114 (3) 536-542
    CrossrefPubMedGoogle Scholar
  • 86 Ortner ME, Caca K, Berr F , et al. Successful photodynamic therapy for nonresectable cholangiocarcinoma: a randomized prospective study. Gastroenterology 2003; 125 (5) 1355-1363
    CrossrefPubMedGoogle Scholar
  • 87 Kahaleh M, Mishra R, Shami VM , et al. Unresectable cholangiocarcinoma: comparison of survival in biliary stenting alone versus stenting with photodynamic therapy. Clin Gastroenterol Hepatol 2008; 6 (3) 290-297
    CrossrefPubMedGoogle Scholar
  • 88 Kniebühler G, Pongratz T, Betz CS , et al. Photodynamic therapy for cholangiocarcinoma using low dose mTHPC (Foscan(®)). Photodiagn Photodyn Ther 2013; 10 (3) 220-228
    CrossrefPubMedGoogle Scholar
  • 89 Lu Y, Liu L, Wu JC , et al. Efficacy and safety of photodynamic therapy for unresectable cholangiocarcinoma: a meta-analysis. Clin Res Hepatol Gastroenterol 2015; ; June 9 (Epub ahead of print); doi: 10.1016/j.clinre.2014.10.015
    PubMedGoogle Scholar
  • 90 Sugarbaker DJ, Wolf AS, Chirieac LR , et al. Clinical and pathological features of three-year survivors of malignant pleural mesothelioma following extrapleural pneumonectomy. Eur J Cardiothorac Surg 2011; 40 (2) 298-303
    PubMedGoogle Scholar
  • 91 Sugarbaker DJ, Richards WG, Bueno R. Extrapleural pneumonectomy in the treatment of epithelioid malignant pleural mesothelioma: novel prognostic implications of combined N1 and N2 nodal involvement based on experience in 529 patients. Ann Surg 2014; 260 (4) 577-580, discussion 580–582
    CrossrefPubMedGoogle Scholar
  • 92 Friedberg JS. Photodynamic therapy for malignant pleural mesothelioma. J Natl Compr Canc Netw 2012; 10 (Suppl. 02) S75-S79
    PubMedGoogle Scholar
  • 93 Moghissi K, Dixon K. Photodynamic therapy in the management of malignant pleural mesothelioma: a review. Photodiagn Photodyn Ther 2005; 2 (2) 135-147
    CrossrefPubMedGoogle Scholar
  • 94 Moghissi K. Photodynamic therapy within global treatment of cancers for thoracic oncology. Royal Society of Chemistry Publication. In press
    PubMedGoogle Scholar
  • 95 Friedberg JS, Culligan MJ, Mick R , et al. Radical pleurectomy and intraoperative photodynamic therapy for malignant pleural mesothelioma. Ann Thorac Surg 2012; 93 (5) 1658-1665 , discussion 1665–1667
    CrossrefPubMedGoogle Scholar
  • 96 Eljamel MS. PDT for brain cancer. In: Hamblin M, Mroz P, eds. Advances in Photodynamic Therapy: Basic, Translational and Clinical. Boston, MA, and London, UK: Artech House; 2008: 495-505
    Google Scholar
  • 97 Perria C, Capuzzo T, Cavagnaro G , et al. Fast attempts at the photodynamic treatment of human gliomas. J Neurosurg Sci 1980; 24 (3–4) 119-129
    PubMedGoogle Scholar
  • 98 Kaye AH, Morstyn G, Brownbill D. Adjuvant high-dose photoradiation therapy in the treatment of cerebral glioma: a phase 1–2 study. J Neurosurg 1987; 67 (4) 500-505
    CrossrefPubMedGoogle Scholar
  • 99 Stylli SS, Kaye AH, MacGregor L, Howes M, Rajendra P. Photodynamic therapy of high grade glioma—long term survival. J Clin Neurosci 2005; 12 (4) 389-398
    CrossrefPubMedGoogle Scholar
  • 100 Marks PV, Belchetz PE, Saxena A , et al. Effect of photodynamic therapy on recurrent pituitary adenomas: clinical phase I/II trial—an early report. Br J Neurosurg 2000; 14 (4) 317-325
    CrossrefPubMedGoogle Scholar
  • 101 Eljamel MS. Photodynamic assisted surgical resection and treatment of malignant brain tumours technique, technology and clinical application. Photodiagn Photodyn Ther 2004; 1 (1) 93-98
    CrossrefPubMedGoogle Scholar
  • 102 Kostron H. Photodynamic diagnosis and therapy and the brain. Methods Mol Biol 2010; 635: 261-280
    PubMedGoogle Scholar
  • 103 Muller P, Wilson B. Photodynamic therapy of brain tumours: postoperative “field fractionation”. J Photochem Photobiol B 1991; 9 (1) 117-119
    CrossrefPubMedGoogle Scholar
  • 104 Stummer W, Pichlmeier U, Meinel T, Wiestler OD, Zanella F, Reulen HJ ; ALA-Glioma Study Group. Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial. Lancet Oncol 2006; 7 (5) 392-401
    Google Scholar
  • 105 Stummer W, Novotny A, Stepp H, Goetz C, Bise K, Reulen HJ. Fluorescence-guided resection of glioblastoma multiforme by using 5-aminolevulinic acid-induced porphyrins: a prospective study in 52 consecutive patients. J Neurosurg 2000; 93 (6) 1003-1013
    CrossrefPubMedGoogle Scholar
  • 106 Eljamel MS, Goodman C, Moseley H. ALA and Photofrin fluorescence-guided resection and repetitive PDT in glioblastoma multiforme: a single centre phase III randomised controlled trial. Lasers Med Sci 2008; 23 (4) 361-367
    CrossrefPubMedGoogle Scholar
  • 107 Moore CM, Pendse D, Emberton M. Photodynamic therapy for prostate cancer—a review of current status and future promise. Nat Clin Pract Urol 2009; 6 (1) 18-30
    CrossrefPubMedGoogle Scholar
  • 108 Eggener SE, Coleman JA. Focal treatment of prostate cancer with vascular-targeted photodynamic therapy. ScientificWorldJournal 2008; 8: 963-973
    CrossrefPubMedGoogle Scholar
  • 109 Pastore AL, Palleschi G, Silvestri L , et al. Prospective randomized study of radiofrequency versus ultrasound scalpels on functional outcomes of laparoscopic radical prostatectomy. J Endourol 2013; 27 (8) 989-993
    CrossrefPubMedGoogle Scholar
  • 110 Bomers JG, Sedelaar JP, Barentsz JO, Fütterer JJ. MRI-guided interventions for the treatment of prostate cancer. AJR Am J Roentgenol 2012; 199 (4) 714-720
    CrossrefPubMedGoogle Scholar
  • 111 Nathan TR, Whitelaw DE, Chang SC , et al. Photodynamic therapy for prostate cancer recurrence after radiotherapy: a phase I study. J Urol 2002; 168 (4 Pt 1) 1427-1432
    CrossrefPubMedGoogle Scholar
  • 112 Moore CM, Nathan TR, Lees WR , et al. Photodynamic therapy using meso tetra hydroxy phenyl chlorin (mTHPC) in early prostate cancer. Lasers Surg Med 2006; 38 (5) 356-363
    CrossrefPubMedGoogle Scholar
  • 113 Patel H, Mick R, Finlay J , et al. Motexafin lutetium-photodynamic therapy of prostate cancer: short- and long-term effects on prostate-specific antigen. Clin Cancer Res 2008; 14 (15) 4869-4876
    CrossrefPubMedGoogle Scholar
  • 114 Azzouzi AR, Barret E, Moore CM , et al. TOOKAD(®) Soluble vascular-targeted photodynamic (VTP) therapy: determination of optimal treatment conditions and assessment of effects in patients with localised prostate cancer. BJU Int 2013; 112 (6) 766-774
    CrossrefPubMedGoogle Scholar
  • 115 Azzouzi AR, Barret E, Bennet J , et al. TOOKAD® Soluble focal therapy: pooled analysis of three phase II studies assessing the minimally invasive ablation of localized prostate cancer. World J Urol 2015; 33 (7) 945-953
    CrossrefPubMedGoogle Scholar
  • 116 Prout Jr GR, Lin CW, Benson Jr R , et al. Photodynamic therapy with hematoporphyrin derivative in the treatment of superficial transitional-cell carcinoma of the bladder. N Engl J Med 1987; 317 (20) 1251-1255
    CrossrefPubMedGoogle Scholar
  • 117 Nseyo UO, Shumaker B, Klein EA, Sutherland K ; Bladder Photofrin Study Group. Photodynamic therapy using porfimer sodium as an alternative to cystectomy in patients with refractory transitional cell carcinoma in situ of the bladder. J Urol 1998; 160 (1) 39-44
    CrossrefPubMedGoogle Scholar
  • 118 D'Hallewin MA, Baert L. Long-term results of whole bladder wall photodynamic therapy for carcinoma in situ of the bladder. Urology 1995; 45 (5) 763-767
    CrossrefPubMedGoogle Scholar
  • 119 Waidelich R, Beyer W, Knüchel R , et al. Whole bladder photodynamic therapy with 5-aminolevulinic acid using a white light source. Urology 2003; 61 (2) 332-337
    CrossrefPubMedGoogle Scholar
  • 120 Kriegmair M, Baumgartner R, Knüchel R, Stepp H, Hofstädter F, Hofstetter A. Detection of early bladder cancer by 5-aminolevulinic acid induced porphyrin fluorescence. J Urol 1996; 155 (1) 105-109, discussion 109–110
    PubMedGoogle Scholar
  • 121 Keefe KA, Tadir Y, Tromberg B , et al. Photodynamic therapy of high-grade cervical intraepithelial neoplasia with 5-aminolevulinic acid. Lasers Surg Med 2002; 31 (4) 289-293
    CrossrefPubMedGoogle Scholar
  • 122 Bodner K, Bodner-Adler B, Wierrani F , et al. Cold-knife conization versus photodynamic therapy with topical 5-aminolevulinic acid (5-ALA) in cervical intraepithelial neoplasia (CIN) II with associated human papillomavirus infection: a comparison of preliminary results. Anticancer Res 2003; 23 (2C): 1785-1788
    PubMedGoogle Scholar
  • 123 Soergel P, Wang X, Stepp H, Hertel H, Hillemanns P. Photodynamic therapy of cervical intraepithelial neoplasia with hexaminolevulinate. Lasers Surg Med 2008; 40 (9) 611-615
    CrossrefPubMedGoogle Scholar
  • 124 Hillemanns P, Untch M, Dannecker C , et al. Photodynamic therapy of vulvar intraepithelial neoplasia using 5-aminolevulinic acid. Int J Cancer 2000; 85 (5) 649-653
    CrossrefPubMedGoogle Scholar
  • 125 Fehr MK, Hornung R, Schwarz VA, Simeon R, Haller U, Wyss P. Photodynamic therapy of vulvar intraepithelial neoplasia III using topically applied 5-aminolevulinic acid. Gynecol Oncol 2001; 80 (1) 62-66
    CrossrefPubMedGoogle Scholar
  • 126 Booth S, Poole D, Moghissi K. Initial experience of the use of photodynamic therapy (PDT) in recurrent malignant and pre-malignant lesions of the vulva. Photodiagn Photodyn Ther 2006; 3 (3) 156-161
    CrossrefPubMedGoogle Scholar
  • 127 Campbell SM, Gould DJ, Salter L, Clifford T, Curnow A. Photodynamic therapy using meta-tetrahydroxyphenylchlorin (Foscan) for the treatment of vulval intraepithelial neoplasia. Br J Dermatol 2004; 151 (5) 1076-1080
    CrossrefPubMedGoogle Scholar
  • 128 Löning M, Diddens H, Küpker W, Diedrich K, Hüttmann G. Laparoscopic fluorescence detection of ovarian carcinoma metastases using 5-aminolevulinic acid-induced protoporphyrin IX. Cancer 2004; 100 (8) 1650-1656
    CrossrefPubMedGoogle Scholar
  • 129 Hendren SK, Hahn SM, Spitz FR , et al. Phase II trial of debulking surgery and photodynamic therapy for disseminated intraperitoneal tumors. Ann Surg Oncol 2001; 8 (1) 65-71
    CrossrefPubMedGoogle Scholar
  • 130 Wakui M, Yokoyama Y, Wang H, Shigeto T, Futagami M, Mizunuma H. Efficacy of a methyl ester of 5-aminolevulinic acid in photodynamic therapy for ovarian cancers. J Cancer Res Clin Oncol 2010; 136 (8) 1143-1150
    CrossrefPubMedGoogle Scholar
  • 131 Khan SA, Dougherty TJ, Mang TS. An evaluation of photodynamic therapy in the management of cutaneous metastases of breast cancer. Eur J Cancer 1993; 29A (12) 1686-1690
    PubMedGoogle Scholar
  • 132 Taber SW, Fingar VH, Wieman TJ. Photodynamic therapy for palliation of chest wall recurrence in patients with breast cancer. J Surg Oncol 1998; 68 (4) 209-214
    CrossrefPubMedGoogle Scholar
  • 133 Cuenca RE, Allison RR, Sibata C, Downie GH. Breast cancer with chest wall progression: treatment with photodynamic therapy. Ann Surg Oncol 2004; 11 (3) 322-327
    CrossrefPubMedGoogle Scholar
  • 134 Liu Y, Hou G, Zhang X, Liu JJ, Zhang S, Zhang J. A pilot randomized clinical study of the additive treatment effect of photodynamic therapy in breast cancer patients with chest wall recurrence. J Breast Cancer 2014; 17 (2) 161-166
    CrossrefPubMedGoogle Scholar
  • 135 Trede M, Schwall G, Saeger HD. Survival after pancreatoduodenectomy. 118 consecutive resections without an operative mortality. Ann Surg 1990; 211 (4) 447-458
    CrossrefPubMedGoogle Scholar
  • 136 Chan HH, Nishioka NS, Mino M , et al. EUS-guided photodynamic therapy of the pancreas: a pilot study. Gastrointest Endosc 2004; 59 (1) 95-99
    CrossrefPubMedGoogle Scholar
  • 137 Bown SG, Rogowska AZ, Whitelaw DE , et al. Photodynamic therapy for cancer of the pancreas. Gut 2002; 50 (4) 549-557
    CrossrefPubMedGoogle Scholar
  • 138 DeLaney TF, Sindelar WF, Tochner Z , et al. Phase I study of debulking surgery and photodynamic therapy for disseminated intraperitoneal tumors. Int J Radiat Oncol Biol Phys 1993; 25 (3) 445-457
    CrossrefPubMedGoogle Scholar
  • 139 Khan T, Unternährer M, Buchholz J , et al. Performance of a contact textile-based light diffuser for photodynamic therapy. Photodiagn Photodyn Ther 2006; 3 (1) 51-60
    CrossrefPubMedGoogle Scholar
  • 140 Cochrane C, Mordon SR, Lesage JC, Koncar V. New design of textile light diffusers for photodynamic therapy. Mater Sci Eng C Mater Biol Appl 2013; 33 (3) 1170-1175
    CrossrefPubMedGoogle Scholar
  • 141 Kim S, Ohulchanskyy TY, Pudavar HE, Pandey RK, Prasad PN. Organically modified silica nanoparticles co-encapsulating photosensitizing drug and aggregation-enhanced two-photon absorbing fluorescent dye aggregates for two-photon photodynamic therapy. J Am Chem Soc 2007; 129 (9) 2669-2675
    CrossrefPubMedGoogle Scholar
  • 142 Chatterjee DK, Fong LS, Zhang Y. Nanoparticles in photodynamic therapy: an emerging paradigm. Adv Drug Deliv Rev 2008; 60 (15) 1627-1637 (Review)
    CrossrefPubMedGoogle Scholar
  • 143 Moghissi K, Dixon K. Is bronchoscopic photodynamic therapy a therapeutic option in lung cancer?. Eur Respir J 2003; 22 (3) 535-541
    CrossrefPubMedGoogle Scholar