Sage (Salvia officinalis) syrup alleviates liver enzymes and kidney functions induced by the carbamate pesticide- methomyl

This study determined the effect of common sage (Salvia officinalis L.) syrup in improving the intoxication of methomyl on liver enzymes, oxidative stress enzymes and kidney functions. Thirty male albino rats weighing 105 ± 15 g were segregated into 6 groups and designed as: G₁ (control); G₂ (sage syrup; 6 g/300 ml); G₃ [mehtomyl at ADI (acceptable daily intake]= 0.03 mg/kg/day); G₄ (methomyl at 1/100 LD₅₀= 0.24 mg/kgBW); G₅ (sage+methomyl at ADI); G₆ (sage+mehtomyl at 1/100 LD₅₀). Sage syrup was given in drinking water, and methomyl was administrated orally by gavages for 28 days. At the end of the experiment, rats were sacrificed and internal organs as well as blood samples were collected. The mean body weight of control was 287.4 g at the end of exposure time which was not differed significantly in G₃ and G₄ groups. Sage syrup group (G₂) showed an increase in body weight which was significant, and G₆ showed a highly significant increase. weights of liver and testes in G₆ were improved and were comparable to those of control group G₁. The high elevation of ALP (442.2 IU/L), ALT (74.6 IU/L) and AST (75.53 IU/L) induced by methomyl at G₄, was considerably lowered by administration of sage syrup in G₆. The ameliorative index (AI) of sage for ALP and ALT equalled 0.9 and 1.1, respectively. The percent of change in MDA (malondialdehyde), TAC (total antioxidant capacity) and SOD (superoxide dismutase) between G₄ (methomyl in high dose) and G₁ (control) were 69.3, 80.2 and 45.0%, respectively. while the percent of change in the same parameters between G₆ (sage+methomyl in high dose) and control group was 5.51, 19.0 and 26.7%, respectively. Such results provide an evidence that sage syrup improved the effect of methomyl intoxication.