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AJP Rep 2016; 06(01): e42-e47
DOI: 10.1055/s-0035-1565923
Case Report
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Neonatal Thrombocytopenia as a Consequence of Maternal Preeclampsia

Ram R. Kalagiri
1   Department of Neonatology, Baylor Scott & White Healthcare, Temple, Texas
2   Baylor Scott & White Healthcare and Texas A&M Health Science Center College of Medicine, Temple, Texas
,
Saiara Choudhury
2   Baylor Scott & White Healthcare and Texas A&M Health Science Center College of Medicine, Temple, Texas
,
Timothy Carder
2   Baylor Scott & White Healthcare and Texas A&M Health Science Center College of Medicine, Temple, Texas
,
Vinayak Govande
3   Department of Pediatrics, Baylor Scott & White Healthcare, Temple, Texas
,
Madhava R. Beeram
1   Department of Neonatology, Baylor Scott & White Healthcare, Temple, Texas
2   Baylor Scott & White Healthcare and Texas A&M Health Science Center College of Medicine, Temple, Texas
3   Department of Pediatrics, Baylor Scott & White Healthcare, Temple, Texas
,
M Nasir Uddin
2   Baylor Scott & White Healthcare and Texas A&M Health Science Center College of Medicine, Temple, Texas
3   Department of Pediatrics, Baylor Scott & White Healthcare, Temple, Texas
4   Departments of Obstetrics & Gynecology, Baylor Scott & White Healthcare, Temple, Texas
5   Department of Internal Medicine, Baylor Scott & White Healthcare, Temple, Texas
› Author Affiliations
Further Information

Publication History

23 July 2015

26 August 2015

Publication Date:
28 October 2015 (online)

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Abstract

Introduction Preeclampsia (preE) is pregnancy-induced hypertension affecting a significant proportion of pregnant women worldwide and can cause detrimental effects in the mother and newborn. Some of the effects in the newborn include neonatal thrombocytopenia. Pertaining specifically to neonatal thrombocytopenia, several questions remain unanswered.

Discussion According to the current literature, neonatal thrombocytopenia due to maternal preE is highly prevalent in the general population and the incidence is reported to be around 30% worldwide. This review gives an insight into the syndrome and summarizes the possible pathological mechanisms, the diagnostic approach, complications, and therapeutic interventions of neonatal thrombocytopenia. It also identifies the involvement of other cell lines, apart from platelets in the newborns. Furthermore, we suggest a future prospective study to investigate the pathogenesis of preE and plan a study involving animal models to come up with a possible therapeutic intervention to prevent preE and its various consequences in neonates.

Keywords

preeclampsia - neonatal thrombocytopenia - pregnancy-induced hypertension
 

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