Download PDF
Int Arch Otorhinolaryngol 2016; 20(04): 294-299
DOI: 10.1055/s-0035-1566305
Original Research
Thieme Publicações Ltda Rio de Janeiro, Brazil

Influence of Hormonal Changes on Audiologic Examination in Normal Ovarian Cycle Females: An Analytic Study

Indri Adriztina
1   Department of Otorhinolaryngology, Universitas Sumatera Utara, Medan, North Sumatera, Indonesia
,
Adlin Adnan
1   Department of Otorhinolaryngology, Universitas Sumatera Utara, Medan, North Sumatera, Indonesia
,
Ichwanul Adenin
2   Department of Obstetrics and Gynecology, Universitas Sumatera Utara, Medan, North Sumatera, Indonesia
,
Siti Hajar Haryuna
1   Department of Otorhinolaryngology, Universitas Sumatera Utara, Medan, North Sumatera, Indonesia
,
Sorimuda Sarumpaet
3   Department of Epidemiology training research advocacy and teaching, Universitas Sumatera Utara, Medan, North Sumatra, Indonesia
› Author Affiliations
Further Information

Publication History

19 August 2015

28 September 2015

Publication Date:
29 October 2015 (online)

Also available at
   Permissions and Reprints

Abstract

Introduction There is only limited information from previous studies that suggest that auditory function may be influenced by hormones. Recent advances in the field have exposed the potential role of hormones in modulating the auditory system.

Objective This study aims to investigate the relationship between menstrual cycle and outer hair cell function with audiological examination.

Methods This is an analytic study with a cross-sectional design. The sampling was a systematic random sampling. We found 49 women with normal menstrual cycle and collected their data through interviews, physical examination, and examination of the ear, with otoscopic and other routine otorhinolaryngology examinations. We evaluated Tympanometry, distortion-product otoacoustic emissions (DPOAE), and pure tone audiometry.

Results We found the audiometric threshold worse in the follicular phase than other phases at 4000 Hz of the right ear, and in the ovulation was found best than any other phases at 1000 Hz of the left ear with significant difference. We found significant difference of DPOAE between ovulation time and follicular phase at 3000 Hz and 1000 Hz in the left ear and between ovulation and luteal phased at 2000 Hz, 3000 Hz and 5000 Hz in the right ear and at 1000 Hz in the left ear with p < 0.05.

Conclusion The result of this study showed that only a small part of audiometry threshold had a significant difference between each menstrual phase. In other words, we found no correlation between menstrual and audiometry threshold. Nonetheless, there is a correlation between menstrual cycle phase and DPOAE amplitude.

Keywords

menstrual cycle - ovulation - luteal phase - follicular phase - DPOAE
 

  • References

  • 1 Hederstierna C, Hultcrantz M, Collins A, Rosenhall U. Hearing in women at menopause. Prevalence of hearing loss, audiometric configuration and relation to hormone replacement therapy. Acta Otolaryngol 2007; 127 (2) 149-155 10.1080/00016480600794446
    CrossrefSearch in Google Scholar
  • 2 Mitre EI, Figueira AS, Rocha AB, Alves SMC. Audiometric and vestibular evaluation in women using the hormonal contraceptive method. Braz J Otorhinolaryngol 2006; 72 (3) 350-354
    CrossrefSearch in Google Scholar
  • 3 Al-Mana D, Ceranic B, Djahanbakhch O, Luxon LM. Alteration in auditory function during the ovarian cycle. Hear Res 2010; 268 (1–2) 114-122
    CrossrefSearch in Google Scholar
  • 4 Arruda PO, Silva IMC. Study of otoacoustic emissions during the female hormonal cycle. Braz J Otorhinolaryngol 2008; 74 (1) 106-111
    CrossrefSearch in Google Scholar
  • 5 Ishii C, Nishino LK, Campos CAH. Vestibular characterization in the menstrual cycle. Braz J Otorhinolaryngol 2009; 75 (3) 375-380
    CrossrefSearch in Google Scholar
  • 6 Mtawalli G, Pina M. Angle, Murphy C. The menstrual cycle and its relation to contraceptive methods: a reference for reproductive health trainers. INTRAH. University of North Caroline; 1997:14
  • 7 Farage MA, Neill S, MacLean AB. Physiological changes associated with the menstrual cycle: a review. Obstet Gynecol Surv 2009; 64 (1) 58-72 10.1097/OGX.0b013e3181932a37
    CrossrefSearch in Google Scholar
  • 8 Poromaa IS, Gingnell M. Menstrual cycle influence on cognitive function and emotion processing – from a reproductive perspective. Front Neurosci 2014; 8: 1-16 10.3389/fnins.2014.00380
    Search in Google Scholar
  • 9 Stenberg AE, Wang H, Fish III J, Schrott-Fischer A, Sahlin L, Hultcrantz M. Estrogen receptors in the normal adult and developing human inner ear and in Turner's syndrome. Hear Res 2001; 157 (1–2) 87-92
    CrossrefPubMedSearch in Google Scholar
  • 10 Charitidi K, Meltser I, Canlon B. Estradiol treatment and hormonal fluctuations during the estrous cycle modulate the expression of estrogen receptors in the auditory system and the prepulse inhibition of acoustic startle response. Endocrinology 2012; 153 (9) 4412-4421
    CrossrefSearch in Google Scholar
  • 11 Yellin MW, Stillman RD. Otoacoustic emissions in normal-cycling females. J Am Acad Audiol 1999; 10 (7) 400-408
    Search in Google Scholar
  • 12 Cox JR. Hormonal influence on auditory function. Ear Hear 1980; 1 (4) 219-222
    CrossrefSearch in Google Scholar
  • 13 Gurbuzler L, Yelken K, Aladag I, Eyibilen A, Koc S. Comparison of transient and distortion-product otoacoustic emissions during the luteal and follicular phases of the menstrual cycle. Ear Nose Throat J 2012; 91 (8) 322-334
    Search in Google Scholar
  • 14 Swanson SJ, Dengerink HA. Changes in puretone threshold and temporary shifts as a function of menstrual cycle and oral contraceptive. J Speech Hear Res 1988; 31 (4) 569-574
    Search in Google Scholar
  • 15 Souaid JP, Rappaport JM. Fluctuating sensorineural hearing loss associated with the menstrual cycle. J Otolaryngol 2001; 30 (4) 246-250
    Search in Google Scholar
  • 16 American Speech-Language Hearig Association. Guidelines for Manual Pure-Tone Threshold Audiometry [Guidelines]. 2005. Available at: www.asha.org/policy . Accesed 15 Jan 2012
  • 17 Al-Mana D, Ceranic B, Djahanbakhch O, Luxon LM. Hormones and the auditory system: a review of physiology and pathophysiology. Neuroscience 2008; 153 (4) 881-900
    CrossrefSearch in Google Scholar
  • 18 Price K, Zhu X, Guimaraes PF, Vasilyeva ON, Frisina RD. Hormone replacement therapy diminishes hearing in peri-menopausal mice. Hear Res 2009; 252 (1–2) 29-36
    CrossrefSearch in Google Scholar
  • 19 Malik V, Shukla GK, Bhatia N. Hearing profile in hypothyroidism. Ind J Otolaryngol Head Neck Surg 2002; 54 (4) 285-290
    Search in Google Scholar
  • 20 Kucur C, Kucur SK, Gozukara I , et al. Extended high frequency audiometry in polycystic ovary syndrome. Scientific World Journal 2013; 2013: 482689
    Search in Google Scholar
  • 21 Walpurger V, Pietrowsky R, Kirschbaum C, Wolf OT. Effects of the menstrual cycle on auditory event-related potentials. Horm Behav 2004; 46 (5) 600-606
    CrossrefSearch in Google Scholar
  • 22 Serra A, Maiolino L, Agnello C, Messina A, Caruso S. Auditory brain stem response throughout the menstrual cycle. Ann Otol Rhinol Laryngol 2003; 112 (6) 549-553
    CrossrefPubMedSearch in Google Scholar
  • 23 Yadav A, Tandon OP, Vaney N. Auditory evoked responses during different phases of menstrual cycle. Indian J Physiol Pharmacol 2002; 46 (4) 449-456
    Search in Google Scholar
  • 24 Mann N, Sidhu RS, Babbar R. Brainstem auditory evoked responses in different phases of menstrual cycle. J Clin Diagn Res 2012; 6 (10) 1640-1643
    Search in Google Scholar
  • 25 Simonoska R Sex steroid hormone receptors: Inner Ear Hearing, Karolinska Insitute, Stockholm, 2009:31
  • 26 Hultcrantz M, Simonoska R, Stenberg AE. Estrogen and hearing: a summary of recent investigations. Acta Otolaryngol 2006; 126 (1) 10-14
    CrossrefPubMedSearch in Google Scholar
  • 27 Nolan LS, Maier H, Hermans-Borgmeyer I , et al. Estrogen-related receptor gamma and hearing function: evidence of a role in humans and mice. Neurobiol Aging 2013; 2077: 1-9
    Search in Google Scholar
  • 28 Kemp DT. Otoacoustic emissions, their origin in cochlear function, and use. Br Med Bull 2002; 63: 223-241
    CrossrefSearch in Google Scholar
  • 29 Wang H, Wu W, Han H, Li B, Wang G, Yu M. Estrogen reduces caspase-3 expression in the inner ear of guinea pigs exposed to stimulated microgravity and inboard noises of spaceship. Int Adv Otol 2014; 10 (10) 25-29 10.5152/lao.2014.005
    CrossrefSearch in Google Scholar
  • 30 Frisina RD. Hormones and hearing: too much or too little of good thing can be ototoxic. Semin Hear 2012; 33 (3) 231-241
    Thieme ConnectSearch in Google Scholar
  • 31 Guimaraes P, Frisina ST, Mapes F, Tadros SF, Frisina DR, Frisina RD. Progestin negatively affects hearing in aged women. Proc Natl Acad Sci U S A 2006; 103 (38) 14246-14249
    CrossrefSearch in Google Scholar