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Semin Reprod Med 2015; 33(06): 384-388
DOI: 10.1055/s-0035-1567824
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Impaired DNA Repair as a Mechanism for Oocyte Aging: Is It Epigenetically Determined?

Shiny Titus
1   Laboratory of Molecular Reproduction and Fertility Preservation, New York Medical College, Valhalla, New York
,
Robert Stobezki
1   Laboratory of Molecular Reproduction and Fertility Preservation, New York Medical College, Valhalla, New York
,
Kutluk Oktay
1   Laboratory of Molecular Reproduction and Fertility Preservation, New York Medical College, Valhalla, New York
2   Department of Obstetrics and Gynecology, New York Medical College, Valhalla, New York
› Author Affiliations
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Publication History

Publication Date:
12 November 2015 (online)

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Abstract

DNA damage is one of the most common insults that challenge all cells, and more so in resting cell-like oocytes. Increased DNA damage in aged oocyte has been shown to negatively impact the reproductive outcomes. The underlying molecular mechanism is still not completely comprehended, but based on the literature, this decline in the aging oocyte is attributed to impaired DNA repair and epigenetic modifications of these genes with increasing age. In this review, we discuss these molecular alterations and the epigenetic modifications in the DNA double strand break repair gene expressions as a mechanism of oocyte aging.

Keywords

oocyte - aging - DNA repair - epigenetics
 

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