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DOI: 10.1055/s-0035-1568355
Antiproliferative Butyrolactones from Mezilaurus crassiramea
Publikationsverlauf
received 14. August 2015
revised 14. August 2015
accepted 15. Januar 2016
Publikationsdatum:
11. Februar 2016 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00027015/201601/lookinside/thumbnails/10-1055-s-0035-1568355_pmleb0038-1.jpg)
Abstract
Bioassay-guided fractionation of the ethanol extract from the leaves of Mezilaurus crassiramea, which was toxic to Artemia salina larvae, afforded 3′-acetylrubrenolide (1), 2′,3′-diacetylrubrenolide (2), and rubrenolide (3) from the active dichloromethane soluble fraction. Compound 1 is new, while 2 and 3 are first reported from a natural source and in the Mezilaurus genus, respectively. Compound 3 showed significant cytotoxicity against UACC-62, MCF-7, HT-29, and PC-3 human cancer cell lines, with GI50 values ranging from 3.3 to 9.9 µg/mL, while 1 and 2 exhibited marginal activities against at least five of the six investigated cell lines. The structures of 1–3 were established on the basis of 1D- and 2D-nuclear magnetic resonance analyses, high-resolution electrospray ionization mass spectrometry data and specific optical rotation values.
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