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J Neurol Surg B Skull Base 2016; 77(04): 319-325
DOI: 10.1055/s-0035-1570347
Original Article
Georg Thieme Verlag KG Stuttgart · New York

Primary Bone Tumors of the Skull: Spectrum of 125 Cases, with Review of Literature

Aanchal Kakkar
1   Department of Pathology, All India Institute of Medical Sciences, New Delhi, India
,
Aruna Nambirajan
1   Department of Pathology, All India Institute of Medical Sciences, New Delhi, India
,
Vaishali Suri
1   Department of Pathology, All India Institute of Medical Sciences, New Delhi, India
,
Chitra Sarkar
1   Department of Pathology, All India Institute of Medical Sciences, New Delhi, India
,
Shashank S. Kale
2   Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India
,
Manmohan Singh
2   Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India
,
Mehar Chand Sharma
1   Department of Pathology, All India Institute of Medical Sciences, New Delhi, India
› Author Affiliations
Further Information

Publication History

08 September 2015

31 October 2015

Publication Date:
04 January 2016 (online)

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Abstract

Aims Primary skull bone tumors, benign or malignant, are rare, and include a vast repertoire of lesions. These tumors are not reported systematically in the literature, with most studies being on individual entities or as single case reports.

Methods Primary bone tumors diagnosed over a period of 12 years were retrieved, histological diagnoses reviewed, and clinical parameters noted.

Results We identified 125 primary skull bone tumors. The mean age at diagnosis was 32 years (range: 2–65 years). Majority of patients were adults (82.4%); male preponderance was noted (72.8%). Malignant tumors were more frequent than benign tumors. Most common malignant tumor was chordoma (n = 37), while most common benign tumor was osteoma (n = 7). Tumors were most frequently located at the skull base, of which clivus was most common location. Chordomas accounted for majority of clival tumors, while chondrosarcoma predominated at other skull base locations. Benign tumors were extremely rare in skull base. Tumors of the vault bones were infrequent; with chondrosarcoma and osteoma being the most common malignant and benign tumors, respectively.

Conclusions This is the largest series of primary skull bone tumors from India. Documentation of such a series will aid in approaching differential diagnosis of skull tumors in a systematic manner.

Keywords

bone tumors - skull - skull base - chondrosarcoma - chordoma
 

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