Idiopathic Polyhydramnios: Severity and Perinatal Morbidity

Samantha L. Wiegand; Carmen J. Beamon; Nancy C. Chescheir; David Stamilio

doi:10.1055/s-0036-1571320

American Journal of Perinatology, Table of Contents

Am J Perinatol 2016; 33(07): 658-664
DOI: 10.1055/s-0036-1571320

Original Article

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Idiopathic Polyhydramnios: Severity and Perinatal Morbidity

Samantha L. Wiegand

¹Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina

,

Carmen J. Beamon

²WakeMed Physician Practices, Maternal- Fetal Medicine, Raleigh, North Carolina

,

Nancy C. Chescheir

¹Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina

,

David Stamilio

¹Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina

› Author Affiliations

Abstract

Objective To estimate the association between the severity of idiopathic polyhydramnios and adverse outcomes.

Study Design Retrospective cohort study of deliveries at one hospital from 2000 to 2012 with an amniotic fluid index (AFI) measurement ≥24 + 0 weeks' gestation. Pregnancies complicated by diabetes, multiples, or fetal anomalies were excluded. Exposure was the degree of polyhydramnios: normal (AFI 5–24 cm), mild (≥ 24–30 cm), and moderate–severe (> 30 cm). Primary outcomes were perinatal mortality, neonatal intensive care unit (NICU) admission, and postpartum hemorrhage.

Results There were 10,536 pregnancies: 10,188 with a normal AFI, 274 mild (78.74%), and 74 moderate–severe polyhydramnios (21.26%). Adverse outcomes were increased with idiopathic polyhydramnios: NICU admission (adjusted odds ratio [AOR] 3.71, 95% confidence interval [CI] 2.77–4.99), postpartum hemorrhage (AOR 15.81, 95% CI 7.82–31.96), macrosomia (AOR 3.41, 95% CI 2.61–4.47), low 5-minute Apgar score (AOR 2.60, 95% CI 1.57–4.30), and cesarean (AOR 2.16, 95% CI 1.74–2.69). There were increasing odds of macrosomia (mild: AOR 3.19, 95% CI 2.36–4.32; moderate–severe: AOR 4.44, 95% CI 2.53–7.79) and low 5-minute Apgar score (mild: AOR 2.24, 95% CI 1.23–4.08; moderate–severe: AOR 3.93, 95% CI 1.62–9.55) with increasing severity of polyhydramnios.

Conclusion Idiopathic polyhydramnios is independently associated with increased risks of morbidity. There appears to be a dose–response relationship for neonatal macrosomia and low 5-minute Apgar score risks.

Keywords

Idiopathic polyhydramnios - amniotic fluid

Full Text

References

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