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Journal of Pediatric Biochemistry 2015; 05(03): 094-097
DOI: 10.1055/s-0036-1571831
Original Article
Georg Thieme Verlag KG Stuttgart · New York

Determination of Relationship between Infection and Serum Levels of Prohepcidin in Pediatric Patients before and after Bone Marrow Transplantation

Bahar Göker
1   Department of Biochemistry, Marmara University, Istanbul, Turkey
,
Meral Akbıyık
2   Department of Oral and Maxillofacial Surgery, Marmara University, Istanbul, Turkey
,
Onur Gönül
2   Department of Oral and Maxillofacial Surgery, Marmara University, Istanbul, Turkey
,
Çağrı Güleç
3   Division of Hematology/Oncology Unit of Bone Marrow Transplantation, Department of Pediatrics, Istanbul University, Istanbul, Turkey
,
Sema Anak
3   Division of Hematology/Oncology Unit of Bone Marrow Transplantation, Department of Pediatrics, Istanbul University, Istanbul, Turkey
› Institutsangaben
Weitere Informationen

Publikationsverlauf

09. Februar 2015

08. April 2015

Publikationsdatum:
28. Januar 2016 (online)

    Lizenzen und Reprints

Abstract

Since the immune system is suppressed before bone marrow transplantation (BMT), severe infections might arise. This clinical article considers the role of prohepcidin, in addition to interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in infections occurring after BMT. Serum prohepcidin, IL-6, TNF-α, and C-reactive protein (CRP) levels were measured in 10 pediatric BMT patients by enzyme-linked immunosorbent assay before and after BMT. The results were evaluated statistically. As a result of the analysis, it was observed that there was a significant correlation between serum prohepcidin and IL-6, TNF-α, and CRP levels in the pretransplantation, posttransplantation, and discharge periods of the patients. The relationship between CRP levels and prohepcidin levels suggests that the serum prohepcidin level might be an important parameter for transplantation patients in consideration of infection. Verification of these results from future studies may confirm the clinical importance of hepcidin.

Keywords

bone marrow transplantation - hepcidin - prohepcidin

Note

This study was sponsored by the Scientific Research Projects Unit of Marmara University (Project No: SAG-C-YLP-070808–0193).


 

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