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DOI: 10.1055/s-0036-1572365
Carotid Intima-Media Thickness in Indonesian Subjects with Cardiovascular Disease Risk Factors Who Were Not Receiving Lipid-Lowering Agents
Publikationsverlauf
Publikationsdatum:
24. Februar 2016 (online)
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Abstract
Carotid intima-media thickness (CIMT) is frequently utilized for detection of subclinical atherosclerosis. This study aims to investigate the association between the CIMT values and demographic characteristics, cardiovascular disease (CVD) risk factors, lipid biochemistry profiles, and high-sensitivity C-reactive protein (hs-CRP) levels among the Indonesian population. Subjects who had two or more CVD risk factors but were not receiving lipid-lowering therapy were recruited from six hospitals of Indonesia. Measurements of CIMT are obtained by ultrasonography of 12 sites within the common carotid artery. CVD risk factors, lipid and glucose profiles, and hs-CRP values were analyzed with respect to distribution of CIMT. The mean–max CIMT was 0.805 ± 0.190 mm (minimum, 0.268 mm; maximum, 1.652 mm) and the mean–mean CIMT was 0.614 ± 0.190 mm (minimum, 0.127 mm; maximum, 1.388 mm). Multivariate analyses confirmed an independent association between increasing CIMT and increasing age (regression coefficient = 0.004; p = 0.004). Our data show normative mean–mean CIMT data for Indonesian subjects with two or more CVD risk factors who are not receiving lipid-lowering therapy, which may guide CVD risk stratification of asymptomatic individuals in Indonesia.
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References
- 1 Ministry of Health Republic of Indonesia. Indonesia's Health Profile 2008. Jakarta: Ministry of Health Republic of Indonesia; 2008
- 2 National Institute of Health Research and Development. Basic Health Research 2007. Jakarta: Ministry of Health of the Republic of Indonesia; 2008
- 3 Zhang Y, Guallar E, Qiao Y, Wasserman BA. Is carotid intima-media thickness as predictive as other noninvasive techniques for the detection of coronary artery disease?. Arterioscler Thromb Vasc Biol 2014; 34 (7) 1341-1345
- 4 van den Oord SC, Sijbrands EJ, ten Kate GL , et al. Carotid intima-media thickness for cardiovascular risk assessment: systematic review and meta-analysis. Atherosclerosis 2013; 228 (1) 1-11
- 5 Oh B-H, Kaligis RWM, Wang Y , et al. Survey of atherosclerotic disease in Asian subjects with cardiovascular disease risk factors who were not receiving lipid-lowering agents. Int J Cardiol 2013; 168 (3) 2761-2766
- 6 Youn YJ, Lee NS, Kim J-Y , et al. Normative values and correlates of mean common carotid intima-media thickness in the Korean rural middle-aged population: the Atherosclerosis RIsk of Rural Areas iN Korea General Population (ARIRANG) study. J Korean Med Sci 2011; 26 (3) 365-371
- 7 Liang Y, Yan Z, Sun B , et al. Cardiovascular risk factor profiles for peripheral artery disease and carotid atherosclerosis among Chinese older people: a population-based study. PLoS ONE 2014; 9 (1) e85927
- 8 Eikendal ALM, Groenewegen KA, Anderson TJ , et al; USE-IMT Project Group. Common carotid intima-media thickness relates to cardiovascular events in adults aged <45 years. Hypertension 2015; 65 (4) 707-713
- 9 Pastorius CA, Medina-Lezama J, Corrales-Medina F , et al. Normative values and correlates of carotid artery intima-media thickness and carotid atherosclerosis in Andean-Hispanics: The Prevencion Study. Atherosclerosis 2010; 211 (2) 499-505
- 10 Bauer M, Delaney JA, Möhlenkamp S , et al; Multi-Ethnic Study of Atherosclerosis; Investigator Group of the Heinz Nixdorf Recall Study. Comparison of factors associated with carotid intima-media thickness in the Multi-ethnic Study of Atherosclerosis (MESA) and the Heinz Nixdorf Recall Study (HNR). J Am Soc Echocardiogr 2013; 26 (6) 667-673
- 11 Azarpazhooh MR, Kazemi-Bajestani SMR, Esmaeili H , et al. Cardiovascular risk factors and nutritional intake are not associated with ultrasound-defined increased Carotid Intima Media Thickness in individuals without a history of cardiovascular events. Int J Prev Med 2014; 5 (11) 1412-1421