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AJP Rep 2016; 06(01): e133-e136
DOI: 10.1055/s-0036-1579624
Case Report
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Seronegative Maternal Ocular Myasthenia Gravis and Delayed Transient Neonatal Myasthenia Gravis

Courtney Townsel
1   Division of Maternal Fetal Medicine, University of Connecticut School of Medicine, Farmington, Connecticut
,
Rebecca Keller
1   Division of Maternal Fetal Medicine, University of Connecticut School of Medicine, Farmington, Connecticut
,
Kendall Johnson
2   Division of Neonatology, Connecticut Children's Medical Center, Farmington, Connecticut
,
Naveed Hussain
2   Division of Neonatology, Connecticut Children's Medical Center, Farmington, Connecticut
,
Winston A. Campbell
1   Division of Maternal Fetal Medicine, University of Connecticut School of Medicine, Farmington, Connecticut
› Author Affiliations
Further Information

Publication History

14 December 2015

27 January 2016

Publication Date:
16 March 2016 (online)

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Abstract

Background Myasthenia gravis (MG) is an autoimmune disorder with fluctuating muscle weakness, divided into generalized and localized (ocular) forms. Maternal antibodies to acetylcholine receptors cross the placenta and may cause transient neonatal myasthenia gravis (TNMG). We present a case of seronegative maternal ocular MG and delayed TNMG.

Case A 29-year-old G3P1011 underwent cesarean birth of a male infant who developed oxygen desaturation requiring supplemental oxygen on day of life (DOL) 3. Based on the clinical course and after exclusion of other diagnoses, the infant was diagnosed with TNMG. Infant's condition improved spontaneously and he was weaned off supplemental oxygen and discharged home on DOL 12.

Conclusion Infants born to mothers with seronegative localized (ocular) MG are also susceptible to TNMG which may be late in onset.

Keywords

ocular myasthenia gravis - pregnancy - transient neonatal myasthenia gravis
 

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