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AJP Rep 2016; 06(01): e129-e132
DOI: 10.1055/s-0036-1579646
Case Report
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Hemolytic Disease of the Fetus and Newborn due to Intravenous Drug Use

Kara B. Markham
1   Department of Obstetrics and Gynecology, The Ohio State University Wexner Medical Center, Columbus, Ohio
,
Scott R. Scrape
2   Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, Ohio
,
Mona Prasad
1   Department of Obstetrics and Gynecology, The Ohio State University Wexner Medical Center, Columbus, Ohio
,
Karen Q. Rossi
3   Department of Obstetrics and Gynecology, Mount Carmel Health System, Columbus, Ohio
,
Richard W. O'Shaughnessy
1   Department of Obstetrics and Gynecology, The Ohio State University Wexner Medical Center, Columbus, Ohio
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Publikationsverlauf

21. Dezember 2015

21. Januar 2016

Publikationsdatum:
16. März 2016 (online)

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Abstract

Objectives The objective is to present a pregnancy complication associated with intravenous drug use, namely, that of red blood cell alloimmunization and hemolytic disease of the fetus and newborn.

Methods An observational case series is presented including women with red blood cell alloimmunization most likely secondary to intravenous drug abuse

Results Five pregnancies were identified that were complicated by red blood cell alloimmunization and significant hemolytic disease of the fetus and newborn, necessitating intrauterine transfusion, an indicated preterm birth, or neonatal therapy.

Conclusions As opioid abuse continues to increase in the United States, clinicians should be aware of the potential for alloimmunization to red blood cell antibodies as yet another negative outcome from intravenous drug abuse.

Keywords

hemolytic disease - fetus - newborn - red blood cell - alloimmunization - intravenous drug use - opiate abuse
 

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