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Clin Colon Rectal Surg 2016; 29(04): 330-335
DOI: 10.1055/s-0036-1582441
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Hamartomatous Polyps and Associated Syndromes

Molly M. Cone
1   Division of Colon and Rectal Surgery, Department of General Surgery, Vanderbilt University Medical Center, Nashville, Tennessee
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Publication History

Publication Date:
21 November 2016 (online)

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Abstract

Hamartomatous polyps of the gastrointestinal tract can occur sporadically, however, for several hereditary syndromes, their presence is one of the major clinical features. Peutz–Jeghers syndrome, juvenile polyposis syndrome, and the PTEN hamartoma syndromes are autosomal dominant inherited disorders that predispose to formation of such polyps, especially in the colon and rectum. These can lead to increased colorectal cancer risk and should be followed and managed appropriately. In this article, the three major hereditary hamartomatous syndromes are described, including presentation, colorectal surveillance, and management.

Keywords

hamartomatous polyposis - Peutz–Jeghers syndrome - juvenile polyposis - PTEN
 

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