Serrated Polyps and Serrated Polyposis Syndrome

Jean H. Ashburn; Thomas P. Plesec; Matthew F. Kalady

doi:10.1055/s-0036-1584088

Clinics in Colon and Rectal Surgery, Inhaltsverzeichnis

Clin Colon Rectal Surg 2016; 29(04): 336-344
DOI: 10.1055/s-0036-1584088

Review Article

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Serrated Polyps and Serrated Polyposis Syndrome

Autor*innen

Jean H. Ashburn

¹Department of Colorectal Surgery, Sanford R. Weiss, MD, Center for Inherited Colorectal Neoplasia, Digestive Diseases Institute, Cleveland Clinic, Cleveland, Ohio
Thomas P. Plesec

²Department of Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio
Matthew F. Kalady

¹Department of Colorectal Surgery, Sanford R. Weiss, MD, Center for Inherited Colorectal Neoplasia, Digestive Diseases Institute, Cleveland Clinic, Cleveland, Ohio

Abstract

Colorectal serrated polyps are intermediate lesions in the serrated neoplastic pathway, which account for up to 30% of colorectal cancers. This pathway is biologically distinct from the adenoma-to-carcinoma sequence, with associated cancers exhibiting mutations in the BRAF oncogene, DNA promoter hypermethylation, and microsatellite instability. An evolving understanding of these unique lesions has led to the development of a more accurate classification, improved endoscopic identification, and tailored clinical management guidelines. This article reviews serrated polyps and serrated polyposis syndrome.

Keywords

serrated polyps - sessile serrated adenoma/polyp - serrated neoplasia - serrated polyposis

Volltext

Referenzen

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