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Journal of Pediatric Epilepsy 2016; 05(03): 116-121
DOI: 10.1055/s-0036-1584669
Review Article
Georg Thieme Verlag KG Stuttgart · New York

Clinical and EEG Features of Idiopathic Focal Epilepsies in Childhood

Roberto H. Caraballo
1   Department of Neurology, Pediatric Hospital “Prof. Dr Juan P Garrahan,” Buenos Aires, Argentina
,
Francesca Darra
2   Servizio di Neuropsichiatria Infantile, Policlinico GB Rossi, Universitá degli studi di Verona, Verona, Italy
,
Bernardo Dalla Bernardina
2   Servizio di Neuropsichiatria Infantile, Policlinico GB Rossi, Universitá degli studi di Verona, Verona, Italy
,
Natalio Fejerman
1   Department of Neurology, Pediatric Hospital “Prof. Dr Juan P Garrahan,” Buenos Aires, Argentina
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Publikationsverlauf

23. März 2016

12. April 2016

Publikationsdatum:
20. Juni 2016 (online)

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Abstract

The International League Against Epilepsy (ILAE) report lists three well-defined syndromes of idiopathic focal epilepsies in childhood: benign childhood epilepsy with centrotemporal spikes (BCECTS), Panayiotopoulos syndrome (PS), and idiopathic childhood occipital epilepsy of Gastaut (ICOE-G). The concept of idiopathic and benign focal epilepsies in childhood is relevant as the term implies absence of structural brain lesions and genetic predisposition in the presence of age-dependent seizures. BCECTS is the most frequent of the benign focal epilepsies in childhood accounting for 15 to 25% of epilepsy syndromes in children below 15 years of age. It is also the most frequent epilepsy syndrome occurring at school age. The prevalence of PS was around 13% in children aged 3 to 6 years with one or more nonfebrile seizures, and 6% in the age group of 1 to 15 years. These figures may be higher if children who are currently considered to have an atypical clinical presentation are included in the syndrome. PS is the most common specific cause of nonfebrile status epilepticus in childhood. ICOE “Gastaut type” is a rare manifestation of a focal idiopathic epilepsy that has an age-related onset and is often age limited. The seizures of ICOE Gastaut type are always of occipital-lobe onset and primarily manifest with visual seizures, which are the most typical and usually the first ictal symptom, but other types of seizures may be associated. ICOE “Gastaut type” is a rare condition with a probable prevalence of 0.2 to 0.9% of all epilepsies, and accounting for 2 to 7% of benign childhood focal seizures.The recognition of these age-dependent epileptic syndromes is crucial for the adequate management of the children and their family.

Keywords

childhood - epilepsy - focal - centrotemporal spikes - occipital spikes - idiopathic
 

  • References

  • 1 Berg AT, Berkovic SF, Brodie MJ , et al. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia 2010; 51 (4) 676-685
    CrossrefPubMedGoogle Scholar
  • 2 Panayiotopoulos CP. Benign Childhood Partial Seizures and Related Epileptic Syndromes. London: John Libbey; 1999
    Google Scholar
  • 3 Fejerman N, Caraballo R. Benign Focal Epilepsies in Infancy, Childhood and Adolescence. London: John Libbey; 2007
    Google Scholar
  • 4 Watanabe K. Benign partial epilepsies. In: Wallace SJ, Farrell K, eds. Epilepsy in Children. 2nd ed. London: Arnold; 2004: 199-220
    CrossrefGoogle Scholar
  • 5 Panayiotopoulos CP. The Epilepsies. Oxfordshire: Bladon Publishing; 2005
    Google Scholar
  • 6 Dalla Bernardina B, Sgro V, Fejerman N. Epilepsy with centrotemporal spikes and related syndromes. In: Roger J, Bureau M, Dravet C, Genton P, Tassinari CA, Wolf P, eds. Epileptic Syndromes in Infancy, Childhood and Adolescence. 4th ed. Montrouge: John Libbey; 2005: 203-225
    Google Scholar
  • 7 Fejerman N. Benign childhood epilepsy with centrotemporal spikes. In: Engel J, Pedley TA, eds. Epilepsy. A Comprehensive Textbook. 2nd ed. Philadelphia, PA: Lippincott, Williams & Wilkins; 2008: 2369-2378
    Google Scholar
  • 8 Panayiotopoulos C, Bureau M, Caraballo R, Dalla Bernardina B, Valeta T. Idiopathic focal epilepsies in childhood. In: Bureau M, Dravet C, Genton P, Delgado Escueta C A, Tassinari CA, et al eds. Epileptic syndromes in Infancy, Childhood and Adolescence. 5th ed. Montrouge: John Libbey; 2012: 217-254
    CrossrefGoogle Scholar
  • 9 Luders H, Lesser RP, Dinner DS, Morris III HH. Benign focal epilepsy of childhood. In: Luders H, Lesser RP, eds. Epilepsy: Electroclinical Syndrome. Berlin: Springer-Verlag; 1987: 303-346
    CrossrefGoogle Scholar
  • 10 Lerman P. Benign childhood epilepsy with centrotemporal spikes. In: Engel J, Pedly TA, eds. Epilepsy: A Comprehensive Textbook. Philadelphia, PA: Lippincott-Raven; 1998: 2307 2314;
    Google Scholar
  • 11 Chahine LM, Mikati MA. Benign pediatric localization-related epilepsies. Epileptic Disord 2006; 8 (4) 243-258
    PubMedGoogle Scholar
  • 12 Stephani U. Typical semiology of benign childhood epilepsy with centrotemporal spikes (BCECTS). Epileptic Disord 2000; 2 (Suppl. 01) S3-S4
    PubMedGoogle Scholar
  • 13 Heijbel J, Bohman M. Benign epilepsy of children with centrotemporal EEG foci: intelligence, behavior, and school adjustment. Epilepsia 1975; 16 (5) 679-687
    CrossrefPubMedGoogle Scholar
  • 14 Staden U, Isaacs E, Boyd SG, Brandl U, Neville BG. Language dysfunction in children with Rolandic epilepsy. Neuropediatrics 1998; 29 (5) 242-248
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 15 Papavasiliou A, Mattheou D, Bazigou H, Kotsalis C, Paraskevoulakos E. Written language skills in children with benign childhood epilepsy with centrotemporal spikes. Epilepsy Behav 2005; 6 (1) 50-58
    CrossrefPubMedGoogle Scholar
  • 16 Monjauze C, Tuller L, Hommet C, Barthez MA, Khomsi A. Language in benign childhood epilepsy with centro-temporal spikes abbreviated form: rolandic epilepsy and language. Brain Lang 2005; 92 (3) 300-308
    CrossrefPubMedGoogle Scholar
  • 17 Deonna T. Rolandic epilepsy: neuropsychology of the active epilepsy phase. Epileptic Disord 2000; 2 (Suppl. 01) S59-S61
    PubMedGoogle Scholar
  • 18 Sart ZH, Demirbilek V, Korkmaz B, Slade PD, Dervent A, Townes BD. The consequences of idiopathic partial epilepsies in relation to neuropsychological functioning: a closer look at the associated mathematical disability. Epileptic Disord 2006; 8 (1) 24-31
    PubMedGoogle Scholar
  • 19 Loiseau P, Duché B. Benign childhood epilepsy with centrotemporal spikes. Cleve Clin J Med 1989; 56 (Suppl Pt 1): S17-S22 , discussion S40–S42
    PubMedGoogle Scholar
  • 20 Mitsudome A, Ohu M, Yasumoto S, Ogawa A. Rhythmic slow activity in benign childhood epilepsy with centrotemporal spikes. Clin Electroencephalogr 1997; 28 (1) 44-48
    CrossrefPubMedGoogle Scholar
  • 21 Ishitobi M, Nakasato N, Yamamoto K, Iinuma K. Opercular to interhemispheric source distribution of benign rolandic spikes of childhood. Neuroimage 2005; 25 (2) 417-423
    CrossrefPubMedGoogle Scholar
  • 22 Dalla Bernardina B, Sgro V, Caraballo R , et al. Sleep and benign partial epilepsies of childhood: EEG and evoked potential study. In: Degen R, Rodin EA, eds. Epilepsy, sleep and Sleep Deprivation. Amsterdam: Elsevier; 1991: 83-96
    Google Scholar
  • 23 Niedermeyer E, Naidu S. Further EEG observations in children with the Rett syndrome. Brain Dev 1990; 12 (1) 53-54
    CrossrefPubMedGoogle Scholar
  • 24 Veggiotti P, Beccaria F, Gatti A, Papalia G, Resi C, Lanzi G. Can protrusion of the tongue stop seizures in Rolandic epilepsy?. Epileptic Disord 1999; 1 (4) 217-220
    PubMedGoogle Scholar
  • 25 de Marco P, Tassinari CA. Extreme somatosensory evoked potential (ESEP): an EEG sign forecasting the possible occurrence of seizures in children. Epilepsia 1981; 22 (5) 569-575
    CrossrefPubMedGoogle Scholar
  • 26 Covanis A. Panayiotopoulos syndrome: a benign childhood autonomic epilepsy frequently imitating encephalitis, syncope, migraine, sleep disorder, or gastroenteritis. Pediatrics 2006; 118 (4) e1237-e1243
    CrossrefPubMedGoogle Scholar
  • 27 Lada C, Skiadas K, Theodorou V, Loli N, Covanis A. A study of 43 patients with panayiotopoulos syndrome, a common and benign childhood seizure susceptibility. Epilepsia 2003; 44 (1) 81-88
    PubMedGoogle Scholar
  • 28 Specchio N, Trivisano M, Di Ciommo V , et al. Panayiotopoulos syndrome: a clinical, EEG, and neuropsychological study of 93 consecutive patients. Epilepsia 2010; 51 (10) 2098-2107
    CrossrefPubMedGoogle Scholar
  • 29 Caraballo R, Cersosimo R, Medina C, Fejerman N. Panayiotopoulos-type benign childhood occipital epilepsy: a prospective study. Neurology 2000; 55 (8) 1096-1100
    PubMedGoogle Scholar
  • 30 Covanis A, Lada C, Skiadas K. Children with Rolandic spikes and ictal vomiting: Rolandic epilepsy or Panayiotopoulos syndrome?. Epileptic Disord 2003; 5 (3) 139-143
    PubMedGoogle Scholar
  • 31 Fejerman N. Early onset childhood occipital epilepsy (Panayiotopoulos type). In: Engel J, Pedley TA, eds. Epilepsy. A Comprehensive Textbook. 2nd ed. Philadelphia, PA: Lippincott, Williams & Wilkins; 2008: 2379-2386
    Google Scholar
  • 32 Caraballo R, Cersósimo R, Fejerman N. Panayiotopoulos syndrome: a prospective study of 192 patients. Epilepsia 2007; 48 (6) 1054-1061
    CrossrefPubMedGoogle Scholar
  • 33 Oguni H, Hayashi K, Imai K, Hirano Y, Mutoh A, Osawa M. Study on the early-onset variant of benign childhood epilepsy with occipital paroxysms otherwise described as early-onset benign occipital seizure susceptibility syndrome. Epilepsia 1999; 40 (7) 1020-1030
    CrossrefPubMedGoogle Scholar
  • 34 Ferrie CD, Caraballo R, Covanis A , et al. Panayiotopoulos syndrome: a consensus view. Dev Med Child Neurol 2006; 48 (3) 236-240
    CrossrefPubMedGoogle Scholar
  • 35 Ferrie CD, Caraballo R, Covanis A , et al. Autonomic status epilepticus in Panayiotopoulos syndrome and other childhood and adult epilepsies: a consensus view. Epilepsia 2007; 48 (6) 1044-1053
    CrossrefPubMedGoogle Scholar
  • 36 Maher J, Ronen GM, Ogunyemi AO, Goulden KJ. Occipital paroxysmal discharges suppressed by eye opening: variability in clinical and seizure manifestations in childhood. Epilepsia 1995; 36 (1) 52-57
    CrossrefPubMedGoogle Scholar
  • 37 Chilosi AM, Brovedani P, Moscatelli M, Bonanni P, Guerrini R. Neuropsychological findings in idiopathic occipital lobe epilepsies. Epilepsia 2006; 47 (Suppl. 02) 76-78
    CrossrefPubMedGoogle Scholar
  • 38 Caraballo RH, Pasteris MC, Portuondo E, Fortini PS. Panayiotopoulos syndrome and diffuse paroxysms as the first EEG manifestation at clinical onset: a study of nine patients. Epileptic Disord 2015; 17 (2) 143-149
    PubMedGoogle Scholar
  • 39 Ohtsu M, Oguni H, Hayashi K, Funatsuka M, Imai K, Osawa M. EEG in children with early-onset benign occipital seizure susceptibility syndrome: Panayiotopoulos syndrome. Epilepsia 2003; 44 (3) 435-442
    CrossrefPubMedGoogle Scholar
  • 40 Yoshinaga H, Koutroumanidis M, Shirasawa A, Kikumoto K, Ohtsuka Y, Oka E. Dipole analysis in panayiotopoulos syndrome. Brain Dev 2005; 27 (1) 46-52
    CrossrefPubMedGoogle Scholar
  • 41 Vigevano F, Ricci S. Benign occipital epilepsy of childhood with prolonged seizures and autonomic symptoms. In: Andermann F, Beaumanoir A, Mira L, Roger J, Tassinari CA, eds. Occipital seizures and epilepsies in Children. London: John Libbey; 1993: 133-140
    Google Scholar
  • 42 Vigevano F, Lispi ML, Ricci S. Early onset benign occipital susceptibility syndrome: video-EEG documentation of an illustrative case. Clin Neurophysiol 2000; 111 (Suppl. 02) S81-S86
    CrossrefPubMedGoogle Scholar
  • 43 Demirbilek V, Dervent A. Panayiotopoulos syndrome: video-EEG illustration of a typical seizure. Epileptic Disord 2004; 6 (2) 121-124
    PubMedGoogle Scholar
  • 44 Covanis A, Ferrie CD, Koutroumanidis M , et al. Panayiotopoulos syndrome and Gastaut type idiopathic childhood occipital epilepsy. In: Roger J, Bureau M, Dravet C, et al., eds. Epileptic Syndromes in Infancy, Childhood and Adolescence. 4th ed. Montrouge: John Libbey; 2005: 227-253
    Google Scholar
  • 45 Kanazawa O, Tohyama J, Akasaka N, Kamimura T. A magnetoencephalographic study of patients with Panayiotopoulos syndrome. Epilepsia 2005; 46 (7) 1106-1113
    CrossrefPubMedGoogle Scholar
  • 46 Saitoh M, Kubota M, Kimura I, Mizuguchi M, Igarashi T. A case of Panayiotopoulos syndrome showing an atypical course. Seizure 2006; 15 (8) 643-648
    CrossrefPubMedGoogle Scholar
  • 47 Gastaut H. A new type of epilepsy: benign partial epilepsy of childhood with occipital spike-waves. Clin Electroencephalogr 1982; 13 (1) 13-22
    CrossrefPubMedGoogle Scholar
  • 48 Gastaut H, Roger J, Bureau M. Benign epilepsy of childhood with occipital paroxysms Up-date. In Roger J, Bureau M, Dravet C, Dreiffus FE, Perret A, Wolf P, eds. Epileptic Syndromes in Infancy, Childhood and adolescence. London: John Libbey; 1992: 201-217
    Google Scholar
  • 49 Caraballo RH, Cersósimo RO, Medina C, Tenembaum S, Fejerman N. Epilepsias parciales idiopáticas con paroxismos occipitales. Rev Neurol (Barc) 1997; 25: 1052-1058
    PubMedGoogle Scholar
  • 50 Caraballo RH, Cersósimo RO, Fejerman N. Childhood occipital epilepsy of Gastaut: a study of 33 patients. Epilepsia 2008; 49 (2) 288-297
    CrossrefPubMedGoogle Scholar
  • 51 Caraballo R, Koutroumanidis M, Panayiotopoulos CP, Fejerman N. Idiopathic childhood occipital epilepsy of Gastaut: a review and differentiation from migraine and other epilepsies. J Child Neurol 2009; 24 (12) 1536-1542
    CrossrefPubMedGoogle Scholar
  • 52 Gastaut H, Zifkin BG. Benign epilepsy of childhood with occipital spike and wave complexes. In: Andermann F, Lugaresi E, eds. Migraine and epilepsy. Boston, MA: Butterworths; 1987: 47-81
    Google Scholar