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Semin Reprod Med 2016; 34(04): 205-214
DOI: 10.1055/s-0036-1585405
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Genetics, Genome-Wide Association Studies, and Menarche

Selma Feldman Witchel
1   Department of Pediatric Endocrinology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania
› Author Affiliations
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Publication History

Publication Date:
11 August 2016 (online)

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Abstract

Puberty is characterized by maturation of the hypothalamic–pituitary–gonadal axis, development of secondary sexual features, increased linear growth velocity, maturation of the epiphyses limiting additional growth, and achievement of menarche. The age at menarche appears to have a significant genetic component. With the advent of genome-wide association studies (GWASs), the genome has been interrogated to find associations between specific loci and age at menarche. It is apparent that multiple genetic loci, epigenetic mechanisms, and environmental factors modulate this biological event crucial for reproductive competence.

Keywords

age at menarche - puberty - GWAS - LIN28B
 

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