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Journal of Pediatric Biochemistry 2012; 02(02): 079-083
DOI: 10.1055/s-0036-1586402
DOI: 10.1055/s-0036-1586402
Review Article
Nitrite: A potential therapeutic avenue for pulmonary disorders
Subject Editor:
Further Information
Publication History
16 August 2011
04 October 2011
Publication Date:
01 August 2016 (online)
Abstract
Nitrite is a stable oxidative metabolic end product of nitric oxide (NO). Nitrite was previously believed to be an inert metabolite of NO that plays a key role in cell physiology and signaling. Until now, research has focused on the usefulness of nitrites as potent biomarkers for several chronic disorders. Recent studies have elucidated its role as a storage reservoir of NO in blood and tissues under hypoxic pathological conditions. Several recent reports have highlighted the therapeutic potential of nitrites in cardiac disorders. This paper will focus on the therapeutic potential of nitrites in chronic lung disorders.