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Journal of Pediatric Biochemistry 2012; 02(03): 159-162
DOI: 10.1055/s-0036-1586406
Review Article
Georg Thieme Verlag KG Stuttgart – New York

Serum lipids and lipoprotein(a) levels in children with idiopathic nephrotic syndrome

Om P. Mishra
a   Departments of Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
,
Rajniti Prasad
a   Departments of Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
,
Divya Atri
a   Departments of Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
,
Surya K. Singh
b   Departments of Endocrinology and Metabolism, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
,
Ziledar Ali
c   Departments of Biochemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
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Publication History

02 January 2012

30 January 2012

Publication Date:
01 August 2016 (online)

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Abstract

The present study was carried out prospectively to evaluate serum lipids and lipoprotein(a) levels in children with nephrotic syndrome during the active phase of disease and during a remission. Serum lipids and lipoprotein(a) levels were measured in 40 children, aged 2–10 years, during the active phase of nephrotic syndrome; 25 with a first attack, 9 infrequent relapsers and 6 frequent relapsers, and during remission and in 20 healthy age-matched controls. The mean serum lipids and lipoprotein(a) levels were significantly raised during the active phase of nephrotic syndrome (p < 0.001). The values were relatively higher in relapsers. The lipids and lipoprotein(a) levels decreased during a remission but were significantly higher (p < 0.05) than controls. Serum lipids had a negative correlation with serum albumin and lipoprotein(a) had a positive correlation with proteinuria (r = 0.5246, p < 0.01) but no correlation with serum albumin. The elevated lipids and lipoprotein(a) in both the active phase of nephrotic syndrome and during remission suggest a possible predisposition to atherosclerosis in future.

Keywords

Lipids - lipoprotein(a) - nephrotic syndrome - relapsers