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CC BY-NC-ND 4.0 · Int Arch Otorhinolaryngol 2017; 21(03): 232-238
DOI: 10.1055/s-0036-1586734
Original Research
Thieme Revinter Publicações Ltda Rio de Janeiro, Brazil

Auditory Evoked Potential Mismatch Negativity in Normal-Hearing Adults

Laura Flach Schwade
1   Department Human Health and Communication, Universidade Federal do Rio Grande do Sul - UFRGS, Ringgold Standard Institution, Porto Alegre, Rio Grande do Sul, Brazil
,
Dayane Domeneghini Didoné
2   Postgraduate Program in Child and Adolescent Health, UFRGS, Porto Alegre, Rio Grande do Sul, Brazil
,
Pricila Sleifer
1   Department Human Health and Communication, Universidade Federal do Rio Grande do Sul - UFRGS, Ringgold Standard Institution, Porto Alegre, Rio Grande do Sul, Brazil
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Publikationsverlauf

10. März 2016

18. Juni 2016

Publikationsdatum:
02. September 2016 (online)

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Abstract

Introduction Mismatch Negativity (MMN) corresponds to a response of the central auditory nervous system.

Objective The objective of this study is to analyze MMN latencies and amplitudes in normal-hearing adults and compare the results between ears, gender and hand dominance.

Methods This is a cross-sectional study. Forty subjects participated, 20 women and 20 men, aged 18 to 29 years and having normal auditory thresholds. A frequency of 1000Hz (standard stimuli) and 2000Hz (deviant stimuli) was used to evoked the MMN.

Results Mean latencies in the right ear were 169.4ms and 175.3ms in the left ear, with mean amplitudes of 4.6µV in the right ear and 4.2µV in the left ear. There was no statistically significant difference between ears. The comparison of latencies between genders showed a statistically significant difference for the right ear, being higher in the men than in women. There was no significant statistical difference between ears for both right-handed and left-handed group. However, the results indicated that the latency of the right ear was significantly higher for the left handers than the right handers. We also found a significant result for the latency of the left ear, which was higher for the right handers.

Conclusion It was possible to obtain references of values for the MMN. There are no differences in the MMN latencies and amplitudes between the ears. Regarding gender, the male group presented higher latencies in relation to the female group in the right ear. Some results indicate that there is a significant statistical difference of the MMN between right- and left-handed individuals.

Keywords

evoked auditory potentials - electrophysiology - event-related potential - evoked potentials - auditory - evoked potentials
 

  • References

  • 1 Brossi AB, Borba KC, Garcia CFD, Reis ACMB, Isaac MdeL. Verification of the Mismatch Negativity (MMN) responses in normal adult subjects. Braz J Otorhinolaryngol 2007; 73 (06) 793-802
    CrossrefGoogle Scholar
  • 2 Matas CG, Hataiama NM, Gonçalves IC. Estabilidade dos potenciais evocados auditivos em indivíduos adultos com audição normal. Rev Soc Bras Fonoaudiol 2011; 16 (01) 37-41
    CrossrefGoogle Scholar
  • 3 ASHA. American Speech-Language Hearing Association. Guidelines for Competencies in Auditory Evoked Potential Measurement and Clinical Applications. Available at: http://www.asha.org/policy/KS2003-00020/ . Accessed May 04, 2015
    Google Scholar
  • 4 Reis ACMB, Frizzo ACF. Potencial Evocado Auditivo Cognitivo. In: Boéchat EM, Menezes PL, Couto CM, Frizzo ACF, Scharlach RC, Anastásio ART. eds. Tratado de Audiologia. São Paulo, Brazil: Santos; 2015: 140-150
    Google Scholar
  • 5 Sleifer P. Avaliação eletrofisiológica da audição em crianças. In: Cardoso MC. (Org.). Fonoaudiologia na infância: avaliação e tratamento. Rio de Janeiro, Brazil: Revinter; 2015: 171-194
    Google Scholar
  • 6 Shiga T, Yabe H, Yu L. , et al. Temporal integration of deviant sound in automatic detection reflected by mismatch negativity. Neuroreport 2011; 22 (07) 337-341
    CrossrefGoogle Scholar
  • 7 Roggia SM. Mismatch Negativity. In: Boéchat EM, Menezes PL, Couto CM, Frizzo ACF, Scharlach RC, Anastásio ART. eds. Tratado de Audiologia. São Paulo, Brazil: Santos; 2015: 151-159
    Google Scholar
  • 8 Näätänen R, Astikainen P, Ruusuvirta T, Huotilainen M. Automatic auditory intelligence: an expression of the sensory-cognitive core of cognitive processes. Brain Res Brain Res Rev 2010; 64 (01) 123-136
    CrossrefGoogle Scholar
  • 9 Soares AJC, Sanches SGG, Lobo IFN, Carvallo RMM, Matas CG, Cárnio MS. Potenciais evocados auditivos de longa latência e processamento auditivo central em crianças com alterações de leitura e escrita: Dados preliminares. Arq Int Otorrinolaringol (Impr.) 2011; 15 (04) 486-491
    Artikel in Thieme ConnectGoogle Scholar
  • 10 Roggia SM, Colares NT. O mismatch negativity em pacientes com distúrbios do processamento auditivo (central). Rev Bras Otorrinolaringol (Engl Ed) 2008; 74 (05) 705-711
    CrossrefGoogle Scholar
  • 11 Rocha-Muniz CN, Befi-Lopes DM, Schochat E. Mismatch negativity in children with specific language impairment and auditory processing disorder. Braz J Otorhinolaryngol 2015; 81 (04) 408-415
    CrossrefGoogle Scholar
  • 12 Näätänen R, Kujala T, Kreegipuu K. , et al. The mismatch negativity: an index of cognitive decline in neuropsychiatric and neurological diseases and in ageing. Brain 2011; 134 (Pt 12): 3435-3453
    CrossrefGoogle Scholar
  • 13 Kaser M, Soltesz F, Lawrence P. , et al. Oscillatory underpinnings of mismatch negativity and their relationship with cognitive function in patients with schizophrenia. PLoS ONE 2013; 8 (12) 1-11
    CrossrefPubMedGoogle Scholar
  • 14 Silva DRO, Carnaúba ATL, Bastos FRA, Andrade MMGB, Andrade KCL, Menezes PL. Mismatch negativity (MMN) e P300 em pacientes com esquizofrenia e com experiências alucinógenas auditivas. Distúrb Comun 2015; 27 (01) 193-195
    Google Scholar
  • 15 Näätänen R. Mismatch negativity: clinical research and possible applications. Int J Psychophysiol 2003; 48 (02) 179-188
    CrossrefGoogle Scholar
  • 16 Santos MAR, Munhoz MSL, Peixoto MAL, Haase VG, Rodrigues JL, Resende LM. Contribuição do mismatch negativity na avaliação cognitiva de indivíduos portadores de esclerose múltipla. Rev Bras Otorrinolaringol (Engl Ed) 2006; 72 (06) 800-807
    CrossrefGoogle Scholar
  • 17 Buranelli G, Barbosa MB, Garcia CF. , et al. Mismatch Negativity (MMN) response studies in elderly subject. Braz J Otorhinolaryngol 2009; 75 (06) 831-838
    Google Scholar
  • 18 Freigang C, Rübsamen R, Richter N. Pre-attentive cortical processing of behaviorally perceptible spatial changes in older adults-a mismatch negativity study. Front Neurosci 2014; 8 (146) 1-10
    Google Scholar
  • 19 Zora H, Schwarz IC, Heldner M. Neural correlates of lexical stress: mismatch negativity reflects fundamental frequency and intensity. Neuroreport 2015; 26 (13) 791-796
    CrossrefGoogle Scholar
  • 20 Garrido MI, Kilner JM, Stephan KE, Friston KJ. The mismatch negativity: a review of underlying mechanisms. Clin Neurophysiol 2009; 120 (03) 453-463
    CrossrefGoogle Scholar
  • 21 Restuccia D, Zanini S, Cazzagon M, Del Piero I, Martucci L, Della Marca G. Somatosensory mismatch negativity in healthy children. Dev Med Child Neurol 2009; 51 (12) 991-998
    CrossrefGoogle Scholar
  • 22 Davis H, Silverman RS. Hearing and deafness. Nova York, NY: Holt, Rinehart & Winston; 1970: 522
    Google Scholar
  • 23 Jerger J. Clinical experience with impedance audiometry. Arch Otolaryngol 1970; 92 (04) 311-324
    CrossrefGoogle Scholar
  • 24 Neves IF, Schochat E. Maturação do processamento auditivo em crianças com e sem dificuldades escolares. Pró Fono R Atual Cient 2005; 17 (03) 311-320
    Google Scholar
  • 25 Cooray GK, Garrido MI, Brismar T, Hyllienmark L. The maturation of mismatch negativity networks in normal adolescence. Clin Neurophysiol 2015; 127: 1-10
    Google Scholar
  • 26 Veras RP, Mattos LC. Audiologia do envelhecimento: revisão de literatura e perspectivas atuais. Rev Bras Otorrinolaringol (Engl Ed) 2007; 73 (01) 128-134
    CrossrefGoogle Scholar
  • 27 Ikezawa S, Nakagome K, Mimura M. , et al. Gender differences in lateralization of mismatch negativity in dichotic listening tasks. Int J Psychophysiol 2008; 68 (01) 41-50
    CrossrefGoogle Scholar
  • 28 Ji LL, Zhang YY, Zhang L, He B, Lu GH. Mismatch negativity latency as a biomarker of amnestic mild cognitive impairment in chinese rural elders. Front Aging Neurosci 2015; 7 (22) 1-5
    Google Scholar
  • 29 Gução ACB. Efeito da variação de freqüência e duração do estímulo no registro do P300 e MMN [masters dissertation]. São Paulo (SP), Brazil: Universidade Estadual Paulista, Faculdade de Filosofia e Ciências de Marília; 2014: 28-31 . Available at: http://repositorio.unesp.br/handle/11449/110546 . Accessed September 27, 2015
    Google Scholar
  • 30 Didoné DD, Garcia MV, da Silveira AF. Long latency auditory evoked potential in term and premature infants. Int Arch Otorhinolaryngol 2014; 18 (01) 16-20
    PubMedGoogle Scholar
  • 31 Asano S, Shiga T, Itagaki S, Yabe H. Temporal integration of segmented-speech sounds probed with mismatch negativity. Neuroreport 2015; 26 (17) 1061-1064
    CrossrefGoogle Scholar
  • 32 Voyer D. Sex differences in dichotic listening. Brain Cogn 2011; 76 (02) 245-255
    CrossrefGoogle Scholar
  • 33 Aerts A, van Mierlo P, Hartsuiker RJ, Santens P, De Letter M. Sex differences in neurophysiological activation patterns during phonological input processing: an influencing factor for normative data. Arch Sex Behav 2015; 44 (08) 2207-2218
    CrossrefPubMedGoogle Scholar
  • 34 Silva TR, Dias FAM. Diferenças na habilidade de integração auditiva inter-hemisférica entre os gêneros feminino e masculino: estudo preliminar. Rev Soc Bras Fonoaudiol 2012; 17 (03) 260-265
    CrossrefGoogle Scholar
  • 35 Flöel A, Buyx A, Breitenstein C, Lohmann H, Knecht S. Hemispheric lateralization of spatial attention in right- and left-hemispheric language dominance. Behav Brain Res 2005; 158 (02) 269-275
    CrossrefGoogle Scholar
  • 36 Mendonça I, Saraiva H, Horácio JLG. A audição dicótica no diagnóstico de dislexia. J Child Adolescent Psychol 2012; 3 (02) 261-275
    Google Scholar
  • 37 Cobianchi A, Dall'Armi V, Giaquinto S. An electrophysiological contribution to the study of language lateralization and prognosis of aphasia. Int J Rehabil Res 2010; 33 (02) 134-141
    CrossrefGoogle Scholar