Diagnosis and Management of Deep Vein Thrombosis and Pulmonary Embolism in Pregnancy

Abstract

Pregnancy-associated venous thromboembolism (PAVTE) consists of deep vein thrombosis and pulmonary embolism (PE) occurring during pregnancy or in the postpartum period. This condition is common and is a major source of morbidity in a population which is young and otherwise relatively healthy. Timely diagnosis and treatment are crucial in ensuring satisfactory patient outcomes. Diagnostic strategies for pregnancy-associated PE in particular require careful consideration of maternal and fetal risks. Low-molecular-weight heparins currently form the mainstay of treatment; however, there are uncertainties around optimal dosing of these agents in certain settings (e.g., obesity). This review discusses the diagnosis and suggested treatment of PAVTE.

Keywords

thrombosis - pulmonary embolism - pregnancy - postpartum

Disclosure

A.B. has previously received conference registration assistance from Sanofi, speaking fees from Bayer, and is a recipient of the CSL Prof. Heimburger award for research unrelated to the topic discussed in this article. S.C. has received speaking fees and grant support from Sanofi and Bayer, and an educational grant from Covidien.

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