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Synthesis 2017; 49(06): 1401-1409
DOI: 10.1055/s-0036-15880098
DOI: 10.1055/s-0036-15880098
paper
Base-Promoted Three-Component One-Pot Approach to 3-(α,α-Diarylmethyl)indoles via Arylation of 3-Indolylalcohols
Further Information
Publication History
Received: 06 September 2016
Accepted after revision: 25 October 2016
Publication Date:
24 November 2016 (online)
Abstract
A base-promoted 3-component one-pot approach to 3-(α,α-diarylmethyl)indoles via arylation of in situ generated 3-indolylalcohols in ethanol–water solvent system is reported. Use of acid catalysts or neutral organocatalysts does not offer the desired product, but furnish bis(indolyl)methanes instead. Electron-rich aromatics such as naphthols and phenols are preferably employed for arylation. The atom economy, use of green solvent, and the multicomponent strategy are the notable features of the reaction.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0036-1588098.
- Supporting Information
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