Cobalt-Catalyzed Perfluoroalkylation of Quinoline Amides at the C5 Position

Published as part of the Special Topic Cobalt in Organic Synthesis

Abstract

An efficient protocol has been developed for the cobalt-catalyzed perfluoroalkylation of 8-aminoquinoline scaffolds. In the presence of 5 mol% of Co(acac)₃ catalyst, the desired products were obtained with exclusive substitution at the C5 position of the quinoline ring after 4 hours. The reaction shows high efficiency and good tolerance for a broad range of functional groups, affording the corresponding products in moderate to good yields.

Key words

cobalt - 8-aminoquinolines - catalysis - fluorine - perfluoroalkyl iodides - perfluoroalkylation

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