Synthesis 2017; 49(11): 2423-2434
DOI: 10.1055/s-0036-1588162
paper
© Georg Thieme Verlag Stuttgart · New York

Copper Acetate Mediated α-Oxysulfonylation of α-Diazo β-Ketosulfones

Chieh-Kai Chan
a   Department of Medicinal and Applied Chemistry, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
,
Heui-Sin Wang
a   Department of Medicinal and Applied Chemistry, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
,
Ru-Ting Hsu*
b   Department of Medical Imaging and Radiology, Shu-Zen Junior College of Medicine and Management, Kaohsiung, 82144, Taiwan   eMail: ruting@ms.szmc.edu.tw   eMail: mychang@kmu.edu.tw
,
Meng-Yang Chang*
a   Department of Medicinal and Applied Chemistry, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
› Institutsangaben
Weitere Informationen

Publikationsverlauf

Received: 28. Dezember 2016

Accepted after revision: 07. März 2017

Publikationsdatum:
30. März 2017 (online)


Abstract

Copper acetate mediated α-oxysulfonylation of α-diazo β-ketosulfones in wet nitromethane under nitrogen provides α-oxysulfonyl β-ketosulfones. The use of different copper salts is investigated for the development of a facile and efficient transformation. A plausible mechanism is proposed herein.

Supporting Information