Copper Acetate Mediated α-Oxysulfonylation of α-Diazo β-Ketosulfones

Chieh-Kai Chan; Heui-Sin Wang; Ru-Ting Hsu; Meng-Yang Chang

doi:10.1055/s-0036-1588162

Synthesis, Table of Contents

Synthesis 2017; 49(11): 2423-2434
DOI: 10.1055/s-0036-1588162

paper

Copper Acetate Mediated α-Oxysulfonylation of α-Diazo β-Ketosulfones

Chieh-Kai Chan

^aDepartment of Medicinal and Applied Chemistry, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan

,

Heui-Sin Wang

^aDepartment of Medicinal and Applied Chemistry, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan

,

Ru-Ting Hsu*

^bDepartment of Medical Imaging and Radiology, Shu-Zen Junior College of Medicine and Management, Kaohsiung, 82144, Taiwan Email: ruting@ms.szmc.edu.tw Email: mychang@kmu.edu.tw

,

Meng-Yang Chang*

^aDepartment of Medicinal and Applied Chemistry, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan

› Author Affiliations

Abstract

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Abstract

Copper acetate mediated α-oxysulfonylation of α-diazo β-ketosulfones in wet nitromethane under nitrogen provides α-oxysulfonyl β-ketosulfones. The use of different copper salts is investigated for the development of a facile and efficient transformation. A plausible mechanism is proposed herein.

Key words

diazo compounds - β-ketosulfones - oxysulfonylation - copper acetate - bond formation

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References

References

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