Modular Regiospecific Synthesis of Nitrated Fatty Acids

^‡ Both authors contributed equally to this study.

Abstract

Endogenous nitrated fatty acids are an important class of signaling molecules. Herein a modular route for the efficient and regiospecific preparation of nitrooleic acids as well as various analogues is described. The approach is based on a simple set of alkyl halides as common building blocks and a Henry reaction/Burgess dehydration sequence for the formation of the key nitroalkene moiety.

Key words

medicinal chemistry - nitroaldol reaction - nitrated fatty ­acid - Burgess reagent - nitroolefin

• References

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