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Synthesis 2016; 48(24): 4471-4476
DOI: 10.1055/s-0036-1588343
DOI: 10.1055/s-0036-1588343
paper
Chiron Approaches to the Antitumor Natural Product Fuzanin D
Further Information
Publication History
Received: 10 August 2016
Accepted after revision: 17 October 2016
Publication Date:
18 November 2016 (online)
Abstract
Fuzanin D, a pyridine-containing natural product, which exhibits cytotoxic activity against DLD-1 cells, is synthesized in a concise manner using l-arabinose or ethyl l-lactate as chiral pool substrates in nine steps (14.4% overall yield) and six steps (30.8% overall yield), respectively. The key steps involve Wittig olefination and olefin cross-metathesis.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0036-1588343.
- Supporting Information
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