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Synthesis 2017; 49(04): 776-789
DOI: 10.1055/s-0036-1588371
DOI: 10.1055/s-0036-1588371
short review
Recent Developments in the Direct Synthesis of Unprotected Primary Amines
Further Information
Publication History
Received: 06 October 2016
Accepted after revision: 14 November 2016
Publication Date:
16 December 2016 (online)
Abstract
A large number of reports describe the formation of the fundamental C–N bond in homogeneous catalysis. Among them, only a few are able to introduce the unprotected amino group, despite the appealing insertion of this key functional group. Recently, a broad range of methods have been reported that enable direct access to the primary amine using either ammonia or other nitrogen sources. In this short review, we illustrate the progress achieved in this field.
1 Introduction
2 Hydroamination
3 Reductive Amination
4 Dehydrogenative Coupling with Alcohols
5 Amination of Aryl Halides and Boronates
6 Allylic Amination
7 C–H Amination
8 Aminofunctionalization
9 Conclusions
-
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Primary amine group was afforded only after cleavage of the protecting group:
For more examples of unprotected aziridine manipulations see: