Fluorous Mixture Synthesis of Tripeptides and Pentapeptides Using­ a Fluorous-Fmoc Protection Strategy

Abstract

A liquid-phase split-type synthesis of various tripeptides and pentapeptides was conducted using a fluorous-Fmoc protection strategy. Fluorous-Fmoc reagents were effectively used as both the protecting group for the amino function and the encoding tag for the amino acid structure. Several of the synthetic peptides prepared showed high activities in an ACE inhibitory assay.

Key words

combinatorial chemistry - peptides - fluorous tag - mixture synthesis - amino acids

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