Catalytic Enantioselective Syntheses of Isoxazolidin-5-ones

Abstract

This short review provides an overview concerning the developments toward the catalytic enantioselective syntheses of isoxazolidin-5-one derivatives making use of metal-based or organocatalytic conditions. The subsequent use and chemical transformations of these valuable chiral oxazole heterocycles will also be described.

1 Introduction

2 Aza-Michael Strategy

3 Nitroso-Based Annulation Strategy

4 Nitrone-Based Annulation Strategy

5 Functionalization Reactions of Isoxazolidin-5-ones

6 Miscellaneous

7 Conclusion

Key words

isoxazolidinones - organocatalysis - organometallics - asymmetric catalysis - Meldrum’s acid

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