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Synthesis 2017; 49(14): 3112-3117
DOI: 10.1055/s-0036-1588785
DOI: 10.1055/s-0036-1588785
paper
An Approach to 3-Oxa-7-azabicyclo[3.3.0]octanes – Bicyclic Morpholine Surrogates
Weitere Informationen
Publikationsverlauf
Received: 02. Februar 2017
Accepted after revision: 21. März 2017
Publikationsdatum:
13. April 2017 (online)
Abstract
An approach to 3-oxa-7-azabicyclo[3.3.0]octanes, bicyclic morpholine analogues, is reported, which relies on [3+2] cycloaddition of maleic anhydrides or furan-2(5H)-ones and an in situ generated azomethine ylide. The utility of the method was demonstrated on a multigram scale.
Key words
cycloaddition - bicyclic compounds - morpholine analogues - conformational restriction - pyrrolidines - oxygen heterocyclesSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1588785.
- Supporting Information
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For selected recent works on synthesis of bicyclic morpholine analogues, see: