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Synthesis 2017; 49(01): 127-134
DOI: 10.1055/s-0036-1588890
DOI: 10.1055/s-0036-1588890
paper
Ruthenium(II)-Catalyzed C−H Methylation with Trifluoroborates
Further Information
Publication History
Received: 31 July 2016
Accepted After revision: 06 September 2016
Publication Date:
26 September 2016 (online)
‡ These authors contributed equally
Dedicated to Professor Dieter Enders
Abstract
A cationic ruthenium(II)-complex enabled unprecedented C–H methylations on indoles and pyrroles. The versatile catalyst proved to be widely applicable and delivered the methylated heteroarenes with excellent levels of positional selectivity and ample substrate scope. The robustness of the catalysts was reflected by the challenging racemization-free C–H methylation of (S)-tryptophan.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0036-1588890.
- Supporting Information
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For selected contributions, see:
For representative examples, see:
Recent examples:
Representative recent reviews on C–H activation:
For recent progress, mostly in palladium and rhodium catalysis, see:
Recent reviews on and examples of ruthenium-catalyzed C–H functionalization:
Examples from our laboratories: