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Synthesis 2017; 49(13): 2933-2938
DOI: 10.1055/s-0036-1588991
DOI: 10.1055/s-0036-1588991
paper
Preparation of Nonradioactive Standards and a Precursor for a Hypoxia 18F PET Tracer Derived from 1-(β-d-Galactopyranosyl)-2-nitroimidazole
Further Information
Publication History
Received: 30 January 2017
Accepted after revision: 10 March 2017
Publication Date:
07 April 2017 (online)
† Deceased.
Abstract
Acetyl-protected 1-(β-d-galactopyranosyl)-2-nitroimidazole was converted to a potential precursor for a fluorine-18 labeled hypoxia tumor marker. Two nonradioactive standards, the 6′-deoxy-6′-fluorogalactosyl and the 4′-deoxy-4′-fluoroglucosyl analogue were also prepared. These 2-nitroimidazole nucleosides were prepared by a modified Vorbrüggen coupling.
Key words
2-nitroimidazole - nucleosides - [18F]fluoride - d-glucose - d-galactose - tumor hypoxia - precursorSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1588991.
- Supporting Information
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