Cobalt-Catalyzed Monoselective ortho-C–H Ethylation of Carboxamides with Triethylaluminum

Kun Xu; Zhoumei Tan; Haonan Zhang; Sheng Zhang

doi:10.1055/s-0036-1589010

Synthesis, Table of Contents

Synthesis 2017; 49(17): 3931-3936
DOI: 10.1055/s-0036-1589010

special topic

Cobalt-Catalyzed Monoselective ortho-C–H Ethylation of Carboxamides with Triethylaluminum

Kun Xu *

College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang, Henan, 473061, P. R. of China Email: xukun@nynu.edu.cn Email: shengzhang@nynu.edu.cn

,

Zhoumei Tan

College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang, Henan, 473061, P. R. of China Email: xukun@nynu.edu.cn Email: shengzhang@nynu.edu.cn

,

Haonan Zhang

College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang, Henan, 473061, P. R. of China Email: xukun@nynu.edu.cn Email: shengzhang@nynu.edu.cn

,

Sheng Zhang*

College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang, Henan, 473061, P. R. of China Email: xukun@nynu.edu.cn Email: shengzhang@nynu.edu.cn

› Author Affiliations

Abstract

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Published as part of the Special Topic Cobalt in Organic Synthesis

Abstract

A 1,10-phenanthroline ligated cobalt catalyst is reported for the ortho-C–H ethylation of aromatic, heteroaromatic, and alkenyl carboxamides with inexpensive triethylaluminum. This reaction represented the first example of cobalt-catalyzed monoselective direct ortho-C–H ethylation reaction with aluminum reagent as an alkyl donor.

Key words

cobalt - ethylation - monoselectivity - organoaluminum - C–H functionalization

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References

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