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Synthesis 2017; 49(14): 3165-3170
DOI: 10.1055/s-0036-1589015
paper
© Georg Thieme Verlag Stuttgart · New York

Synthesis of 3-Formylbenzenesulfonyl Chloride Derivatives

Xuefei Bao
Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, P. R. of China   eMail: chenguoliang@syphu.edu.cn
,
Ziao Liu
Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, P. R. of China   eMail: chenguoliang@syphu.edu.cn
,
Xinjie Liang
Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, P. R. of China   eMail: chenguoliang@syphu.edu.cn
,
Dake Song
Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, P. R. of China   eMail: chenguoliang@syphu.edu.cn
,
Tao Shi
Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, P. R. of China   eMail: chenguoliang@syphu.edu.cn
,
Xuan Zhao
Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, P. R. of China   eMail: chenguoliang@syphu.edu.cn
,
Changshun Bao
Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, P. R. of China   eMail: chenguoliang@syphu.edu.cn
,
Guoliang Chen*
Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, P. R. of China   eMail: chenguoliang@syphu.edu.cn
› InstitutsangabenGefördert durch: Discipline Construction Program of Shenyang Pharmaceutical University (52134606)
Gefördert durch: Natural Science Foundation of Liaoning Province (201602707)
Weitere Informationen

Publikationsverlauf

Received: 22. Januar 2017

Accepted after revision: 01. April 2017

Publikationsdatum:
05. Mai 2017 (online)

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Abstract

A synthetic route to 3-formylbenzenesulfonyl chloride derivatives from the corresponding benzaldehydes has been developed. The key step in this procedure is the conversion of aldehyde bisulfite adducts to target compounds via a two-stage reaction in the presence of Na2SO4. A series of 3-formylbenzenesulfonyl chloride derivatives were prepared by this method and identified by chemical derivatization method.

Key words

3-formylbenzenesulfonyl chloride - aldehyde sodium bisulfite - chlorosulfonation - two-stage reaction - chemical derivatization method

Supporting Information

    Supporting information for this article is available online at https://doi.org /10.1055/s-0036-1589015.
  • Supporting Information

Primary Data

    Primary data for this article are available online at http://www.thieme-connect.com/ejournals/toc/synthesis and can be cited using the following DOI: 10.4125/pd0093th.

  • Primary Data
 

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