Synthesis 2017; 49(18): 4327-4334
DOI: 10.1055/s-0036-1589024
paper
© Georg Thieme Verlag Stuttgart · New York

Asymmetric Friedel–Crafts/Michael Reaction of Indoles and Pyrroles with Coumarin-3-carbonylates

Victor G. Desyatkin
Lomonosov Moscow State University, Department of Chemistry, Leninskie Gory, Moscow, 119991, Russian Federation   eMail: beletska@org.chem.msu.ru
,
Irina P. Beletskaya*
Lomonosov Moscow State University, Department of Chemistry, Leninskie Gory, Moscow, 119991, Russian Federation   eMail: beletska@org.chem.msu.ru
› Institutsangaben
This study was performed under financial support of the Russian Science Foundation (Grant 14-23-00186).
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Publikationsverlauf

Received: 27. März 2017

Accepted: 07. April 2017

Publikationsdatum:
07. Juni 2017 (online)


Abstract

Asymmetric Friedel–Crafts reactions of indoles or pyrroles with coumarin-3-carboxylates catalyzed by Cu(OTf)2 complexes with chiral bis(oxazoline) ligands have been developed. The highest ee (up to 82%) was achieved for indole with a nitro derivative of coumarin-3-carboxylate­.

Supporting Information