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Synthesis 2018; 50(05): 1159-1165
DOI: 10.1055/s-0036-1589136
DOI: 10.1055/s-0036-1589136
paper
Synthesis of New Annulated Pyrazinothienotriazolopyrimidinones and Triazolylthienopyrazines
Further Information
Publication History
Received: 25 September 2017
Accepted after revision: 21 October 2017
Publication Date:
23 November 2017 (online)
Abstract
New pyrazino[2′,3′:4,5]thieno[2,3-e][1,2,3]triazolo[1,5-a]-pyrimidin-5(4H)-ones were synthesized in an efficient, fast, and mild one-pot procedure from methyl 7-azidothieno[2,3-b]pyrazine-6-carboxylate. From the latter, some triazolothieno[2,3-b]pyrazine-6-carboxylates were also obtained with total regioselectivity by [2+3] cycloaddition with alkynes without any metal catalyst.
Key words
heterocycle - pyrazinothienopyrimidines - thienopyrazines - cycloaddition - one-pot cyclizationsSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1589136.
- Supporting Information
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