Palladium-Catalyzed Synthesis of Aryl and Heteroaryl Difluoromethylated Phosphonates

Published as part of the Bürgenstock Special Section 2017 Future Stars in Organic Chemistry

Abstract

We report the palladium-catalyzed introduction of the di­fluoromethylposphonate unit onto aryl and heteroaryl iodides under mild conditions. Using the CuCF₂PO(OEt)₂ species generated in situ, the method allows the functionalization of various otherwise reluctant substrates. In addition, this reaction permits the formation of CF₂PO(OEt)₂-containing heterocycles, an important class of compounds. This process broadens the current toolbox of methods available to construct CF₂PO(OEt)₂-containing molecules.

Key words

fluorine - phosphate mimic - synthetic method - palladium - copper

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